Abstract

A green synthetic approach for the expedite construction of thirty six thioether linked 1,2,3-triazoles was carried out using Cellulose supported CuI nanoparticles in water. The structure of synthesized triazoles was explicated by spectroscopic techniques like FTIR, ¹H NMR, ¹³C NMR, HRMS and evaluated for in vitro antibacterial potential against Staphylococcus aureus, Bacillus subtilis, Escherichia coli and Klebsiella pneumoniae. Most of synthesized triazole derivatives exhibited average to good inhibitory activity. However, compound 6x showed appreciable potent activity against the tested bacterial strains. In silico ADME analysis showed the good bioavailability of the compounds.

摘要

使用纤维素支持的 CuI 纳米粒子在水中进行了一种绿色合成方法，用于加速构建 36 个硫醚连接的 1,2,3-三唑。合成的三唑类化合物的结构通过 FTIR、¹ H NMR、¹³ C NMR、HRMS 等光谱技术进行了解释，并评估了对金黄色葡萄球菌、枯草芽孢杆菌、大肠杆菌和肺炎克雷伯菌的体外抗菌潜力。大多数合成的三唑衍生物表现出平均到良好的抑制活性。然而，化合物6x对测试的细菌菌株显示出明显的有效活性。电脑模拟 ADME 分析表明这些化合物具有良好的生物利用度。