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Knowledge gaps in late-onset neonatal sepsis in preterm neonates: a roadmap for future research
Pediatric Research ( IF 3.6 ) Pub Date : 2021-09-08 , DOI: 10.1038/s41390-021-01721-1
Serife Kurul 1 , Kinga Fiebig 1, 2 , Robert B Flint 1, 3 , Irwin K M Reiss 1 , Helmut Küster 4 , Sinno H P Simons 1 , Swantje Voller 1, 2 , H Rob Taal 1
Affiliation  

Abstract

Late-onset neonatal sepsis (LONS) remains an important threat to the health of preterm neonates in the neonatal intensive care unit. Strategies to optimize care for preterm neonates with LONS are likely to improve survival and long-term neurocognitive outcomes. However, many important questions on how to improve the prevention, early detection, and therapy for LONS in preterm neonates remain unanswered. This review identifies important knowledge gaps in the management of LONS and describe possible methods and technologies that can be used to resolve these knowledge gaps. The availability of computational medicine and hypothesis-free-omics approaches give way to building bedside feedback tools to guide clinicians in personalized management of LONS. Despite advances in technology, implementation in clinical practice is largely lacking although such tools would help clinicians to optimize many aspects of the management of LONS. We outline which steps are needed to get possible research findings implemented on the neonatal intensive care unit and provide a roadmap for future research initiatives.

Impact

  • This review identifies knowledge gaps in prevention, early detection, antibiotic, and additional therapy of late-onset neonatal sepsis in preterm neonates and provides a roadmap for future research efforts.

  • Research opportunities are addressed, which could provide the means to fill knowledge gaps and the steps that need to be made before possible clinical use.

  • Methods to personalize medicine and technologies feasible for bedside clinical use are described.



中文翻译:

早产儿迟发性新生儿败血症的知识差距:未来研究的路线图

摘要

迟发性新生儿败血症 (LONS) 仍然是新生儿重症监护病房中早产儿健康的重要威胁。优化 LONS 早产新生儿护理的策略可能会提高生存率和长期神经认知结果。然而,关于如何改善早产儿 LONS 的预防、早期发现和治疗的许多重要问题仍未得到解答。本综述确定了 LONS 管理中的重要知识差距,并描述了可用于解决这些知识差距的可能方法和技术。计算医学和无假设组学的可用性方法让位于建立床边反馈工具以指导临床医生对 LONS 进行个性化管理。尽管技术取得了进步,但临床实践中的实施在很大程度上缺乏,尽管这些工具将帮助临床医生优化 LONS 管理的许多方面。我们概述了在新生儿重症监护病房实施可能的研究结果所需的步骤,并为未来的研究计划提供路线图。

影响

  • 本综述确定了早产儿迟发性新生儿败血症的预防、早期检测、抗生素和额外治疗方面的知识差距,并为未来的研究工作提供了路线图。

  • 研究机会得到解决,这可以提供填补知识空白的方法以及在可能的临床使用之前需要采取的步骤。

  • 描述了可用于床边临床使用的个性化药物和技术的方法。

更新日期:2021-09-08
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