Understanding the biomechanical phenomena governing the intercellular space can be considered as an effective tool for the treatment of tumors and cancerous tissues. One of the factors that plays a significant role in the quality and efficiency of the drug delivery process to tumors and cancerous tissues as one of the influential biomechanical factors is the osmotic pressure in the interstitial fluid in the intercellular space of tumors. In this study, the effect of osmotic pressure on the distribution of stress and strain in a tumor tissue is investigated in two modes using a poro-elastic and two-dimensional model. The results of this study show that the effect of osmotic pressure and change in the circumference of tumor tissue causes a decrease or increase in mechanical stress and strain, which can be used to control the tumor growth for treatment. In fact, according to the results, by isolating the tumor tissue (This refers to a condition in which tumor cells have grown in rigid containers) and considering the osmotic pressure, the stress created in the tissue is reduced, but if the tumor tissue is surrounded by healthy tissue and osmotic pressure is applied to it, the stress to increase by about 30 Pa compared to when these two assumptions are not considered.

了解控制细胞间隙的生物力学现象可以被认为是治疗肿瘤和癌组织的有效工具。作为有影响的生物力学因素之一，对肿瘤和癌组织的药物递送过程的质量和效率起重要作用的因素之一是肿瘤细胞间隙中的组织液中的渗透压。在这项研究中，使用多孔弹性和二维模型以两种模式研究渗透压对肿瘤组织中应力和应变分布的影响。这项研究的结果表明，渗透压的影响和肿瘤组织周长的变化导致机械应力和应变的减少或增加，可用于控制肿瘤生长进行治疗。事实上，根据结果，通过隔离肿瘤组织（这是指肿瘤细胞在刚性容器中生长的情况）并考虑渗透压，组织中产生的压力会降低，但如果肿瘤组织是被健康组织包围并对其施加渗透压时，与不考虑这两个假设时相比，压力增加了约 30 Pa。