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Role of mucoadhesive polymers in retention of toothpaste in the oral cavity
Colloids and Surfaces B: Biointerfaces ( IF 5.8 ) Pub Date : 2021-09-08 , DOI: 10.1016/j.colsurfb.2021.112104
Sam R Aspinall 1 , Jane K Parker 2 , Vitaliy V Khutoryanskiy 1
Affiliation  

Retention of active ingredients of toothpastes in the mouth following brushing determines the efficiency of these oral care formulations. In this study, new in vitro methodologies for the observation and measurement of toothpaste retention in the oral cavity were developed and used to evaluate the efficiency of formulations containing different mucoadhesive hydrophilic polymers. The findings suggest that using Carbopol ETD 2020 and Carbopol Ultrez 10 as binders in toothpaste prolongs the retention time of these formulations in the oral cavity. The in vitro methodologies tested, coupled with texture analysis, were able to accurately characterise the behaviour of the toothpaste and produce detailed images showing how it is retained in the oral cavity. This study has not only produced a new method for studying the behaviour of toothpaste and other formulations in the oral cavity but is also the first to investigate how different types of mucoadhesive binders can be used to improve toothpaste retention.



中文翻译:

粘膜粘附聚合物在牙膏在口腔中的保留中的作用

刷牙后牙膏的活性成分在口腔中的保留决定了这些口腔护理配方的效率。在这项研究中,开发了用于观察和测量牙膏在口腔中滞留的新体外方法,并用于评估含有不同粘膜粘附亲水聚合物的配方的效率。研究结果表明,使用 Carbopol ETD 2020 和 Carbopol Ultrez 10 作为牙膏中的粘合剂可延长这些配方在口腔中的保留时间。在体外测试的方法与质地分析相结合,能够准确表征牙膏的行为,并生成详细图像,显示牙膏如何保留在口腔中。这项研究不仅为研究牙膏和其他配方在口腔中的行为提供了一种新方法,而且还首次研究了如何使用不同类型的粘膜粘合剂来改善牙膏的保留。

更新日期:2021-09-14
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