A modular multiphase flow crystallizer set-up for the continuous crystallization of paracetamol with an in-line nuclei generator has been developed. Gas bubbles are introduced in a capillary to provide heterogeneous nucleation sites and enhance the nucleation rate. Taking advantage of the separate nucleation and growth sections, control over crystal size distribution is achieved without compromising its span. Comparison with batch growth showed smaller crystal sizes as well as narrower span for the continuous growth. Different configurations of the setup were investigated with regard to the presence of the gas in nucleation and growth sections. Reproducible results were only obtained when gas is present both in the nucleation section (as microbubbles) and in the growth section (as gas slugs). Yields of up to 71% were obtained. Taking the growth time and temperature as varying parameters, the mean crystal size could be manipulated.

已经开发了一种模块化多相流结晶器装置，用于使用在线核发生器连续结晶对乙酰氨基酚。在毛细管中引入气泡以提供异质成核位点并提高成核速率。利用单独的成核和生长部分，可以在不影响其跨度的情况下实现对晶体尺寸分布的控制。与批量生长的比较显示出更小的晶体尺寸以及更窄的连续生长跨度。关于成核和生长部分中气体的存在，研究了装置的不同配置。只有在成核部分（作为微气泡）和生长部分（作为气体段塞）都存在气体时，才能获得可重复的结果。获得了高达 71% 的产率。