A visible light mediated stereospecific C(sp²)–H difluoroalkylation of (Z)-aldoximes to (E)-difluoroalkylated ketoximes has been described. In this reaction, (hetero)-aromatic and aliphatic difluoroalkylated ketoximes could be obtained with the retention of the configuration of the starting aldoximes. A preliminary mechanism study showed that a difluoromethyl radical via an SET pathway was involved.

中文翻译：

---

(Z)-醛肟的可见光介导的立体定向 C(sp2)-H 二氟烷基化

已经描述了可见光介导的 ( Z )-醛肟到 ( E )-二氟烷基化酮肟的立体定向 C(sp ² )-H 二氟烷基化。在该反应中，(杂)-芳香族和脂肪族二氟烷基化酮肟可以在保留起始醛肟构型的情况下获得。初步机制研究表明，涉及通过SET 途径的二氟甲基自由基。