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Direct conversion of secondary propargyl alcohols into 1,3-di-arylpropanone via DBU promoted redox isomerization and palladium assisted chemoselective hydrogenation in a single pot operation
New Journal of Chemistry ( IF 3.3 ) Pub Date : 2021-08-17 , DOI: 10.1039/d1nj02972j
Rimpa De 1 , S. Antony Savarimuthu 2 , Shubhadeep Chandra 3 , Mrinal K. Bera 1
Affiliation  

Palladium(II)acetate is found to be an efficient catalyst for the single-step conversion of secondary propargyl alcohols to 1,3-diarylpropanone derivatives under mild basic conditions. The reaction is believed to proceed via redox isomerisation of secondary propargyl alcohols followed by chemoselective reduction of an enone double bond with formic acid as an adequate hydrogen donor. A large number of 1,3-diarylpropanone derivatives may readily be prepared from a milligram to a multigram scale.

中文翻译:

在单锅操作中通过 DBU 促进氧化还原异构化和钯辅助化学选择性氢化将仲炔醇直接转化为 1,3-二芳基丙酮

发现乙酸钯 ( II ) 是一种有效的催化剂,可在温和的碱性条件下将仲炔醇一步转化为 1,3-二芳基丙酮衍生物。据信,该反应通过仲炔丙醇的氧化还原异构化,然后用甲酸作为适当的氢供体对烯酮双键进行化学选择性还原而进行。大量的 1,3-二芳基丙酮衍生物可以很容易地从毫克级到几克级制备。
更新日期:2021-09-08
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