Serotonergic and Dopaminergic Lesions Underlying Parkinsonian Neuropsychiatric Signs,Movement Disorders

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Serotonergic and Dopaminergic Lesions Underlying Parkinsonian Neuropsychiatric Signs
Movement Disorders ( IF 8.6 ) Pub Date : 2021-09-08 , DOI: 10.1002/mds.28722
Audrey Maillet _{1,

2} , Elise Météreau _{1,

2,

3} , Léon Tremblay _{1,

2} , Emilie Favre _{3,

4} , Hélène Klinger ₃ , Eugénie Lhommée _{5,

6} , Didier Le Bars _{7,

8} , Anna Castrioto _{5,

6} , Stéphane Prange _{1,

2,

9} , Véronique Sgambato _{1,

2} , Emmanuel Broussolle _{1,

2,

9} , Paul Krack _{5,

6,

10} , Stéphane Thobois _{1,

2,

9}

Affiliation

CNRS, Institut des Sciences Cognitives Marc Jeannerod, UMR 5229 CNRS, Lyon, France.
Université Claude Bernard Lyon I, Lyon, France.
Hospices Civils de Lyon, Hôpital Neurologique Pierre Wertheimer, Service de Neurologie C, Lyon, France.
Genopsy, Centre Hospitalier Le Vinatier, Lyon, France.
Université Grenoble Alpes, Grenoble Institut des Neurosciences, Inserm U1216, Grenoble, France.
Unité des Troubles du Mouvement, Département de Neurologie, CHU de Grenoble, Grenoble, France.
CERMEP, Imagerie du Vivant, Lyon, France.
Institut de Chimie et de Biochimie Moléculaires et Supramoléculaires, UMR 5246 CNRS, Université Claude Bernard Lyon I, Lyon, France.
Faculté de médecine Lyon Sud Charles Mérieux, Univ Lyon, Université Claude Bernard Lyon I, Lyon, France.
Department of Neurology, Center for Parkinson's Disease and Movement Disorders, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.

Parkinson's disease (PD) is characterized by heterogeneous motor and nonmotor manifestations related to alterations in monoaminergic neurotransmission systems. Nevertheless, the characterization of concomitant dopaminergic and serotonergic dysfunction after different durations of Parkinson's disease, as well as their respective involvement in the expression and severity of neuropsychiatric signs, has gained little attention so far.

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