The development of photothermal agents with high photothermal conversion efficiency (PCE) can help to reduce drug and laser dosage, but still remains a big challenge. Herein, a novel approach is reported to design photothermal agents with high PCE values by promoting nonradiative heat generation processes through the cooperation of twisted intramolecular charge transfer (TICT) and molecular motions. Within the designed molecule 2DMTT-BBTD, the tetraphenylethenes act as molecular rotors, the long alkyl chain grafted thiophene helps to twist the molecular geometry to facilitate TICT state formation and preserve molecular motions in aggregate, while the strong electron-withdrawing BBTD unit enhances TICT effect. 2DMTT-BBTD exhibits NIR-absorption and a high PCE value of 74.8% under 808 nm laser irradiation. Gambogic acid (GA) which surmounts tumor cell thermotolerance by inhibiting heat shock protein 90 (HSP90) expression is coloaded into the nanoparticles, RGD peptide is further introduced to the nanoparticle surface to improve tumor accumulation. The resultant nanoparticles facilitate the effective low-temperature hyperthermia therapy of muscle-invasive bladder cancer (MIBC) with minimal damage to surrounding heathy tissues. This work delivers a new design concept for development of highly efficient photothermal agents, which also provides a safer approach for noninvasive treatment of MIBC and other malignant tumors.

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通过 TICT 和分子运动促进光热疗法用于肌肉浸润性膀胱癌的光热疗

开发具有高光热转换效率（PCE）的光热剂有助于减少药物和激光剂量，但仍然是一个很大的挑战。本文报道了一种通过扭曲分子内电荷转移 (TICT) 和分子运动的合作促进非辐射发热过程来设计具有高 PCE 值的光热剂的新方法。在设计的分子 2DMTT-BBTD 中，四苯基乙烯充当分子转子，长烷基链接枝噻吩有助于扭转分子几何形状以促进 TICT 状态形成并保持分子整体运动，而强吸电子 BBTD 单元增强了 TICT 效应. 2DMTT-BBTD 在 808 nm 激光照射下表现出近红外吸收和 74.8% 的高 PCE 值。通过抑制热休克蛋白 90 (HSP90) 表达来克服肿瘤细胞耐热性的藤黄酸 (GA) 被共同加载到纳米颗粒中，进一步将 RGD 肽引入纳米颗粒表面以改善肿瘤积累。由此产生的纳米粒子有助于对肌肉浸润性膀胱癌 (MIBC) 进行有效的低温热疗，同时对周围健康组织的损伤最小。这项工作为高效光热剂的开发提供了新的设计理念，也为MIBC等恶性肿瘤的无创治疗提供了一种更安全的方法。由此产生的纳米粒子有助于对肌肉浸润性膀胱癌 (MIBC) 进行有效的低温热疗，同时对周围健康组织的损伤最小。这项工作为高效光热剂的开发提供了新的设计理念，也为MIBC等恶性肿瘤的无创治疗提供了一种更安全的方法。由此产生的纳米粒子有助于对肌肉浸润性膀胱癌 (MIBC) 进行有效的低温热疗，同时对周围健康组织的损伤最小。这项工作为高效光热剂的开发提供了新的设计理念，也为MIBC等恶性肿瘤的无创治疗提供了一种更安全的方法。