A series of Pt(0)-η²-olefin complexes bearing 1,3,5-triaza-7-phosphaadamantane (PTA) or N-heterocyclic carbenes are prepared following different synthetic strategies depending on the nature of coordinated alkene and spectator ligands. These new platinum(0) derivatives have been tested in vitro as anticancer agents toward three different tumor (human ovarian cancer A2780 and A2780cis and K562 myelogenous leukemia) and one non-tumor (Hacat keratinocytes) cell lines, proving to be in several cases highly and selectively cytotoxic against ovarian cancer cells. Furthermore, this antiproliferative effect is associated with the activation of an apoptosis process.

中文翻译：

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含 1,3,5-triaza-7-phosphaadamantane 和 N-杂环卡宾配体的 Pt(0)-烯烃配合物的合成及抗癌活性

一系列的Pt（0） - η ^2个烯烃络合物轴承1,3,5-三氮杂-7-磷（PTA）或ñ -杂环卡宾制备以下根据协调的烯烃和旁观者的配体的性质不同的合成策略。这些新的铂 (0) 衍生物已在体外测试作为抗癌剂用于三种不同的肿瘤（人卵巢癌 A2780 和 A2780顺式和 K562 骨髓性白血病）和一种非肿瘤（Hacat 角质形成细胞）细胞系，证明在几种情况下有效对卵巢癌细胞具有高度和选择性的细胞毒性。此外，这种抗增殖作用与细胞凋亡过程的激活有关。