当前位置:
X-MOL 学术
›
Int. J. Gen. Med.
›
论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Factors Associated with Mortality Among Hospitalized Adults with COVID-19 Pneumonia at a Private Tertiary Hospital in Tanzania: A Retrospective Cohort Study
International Journal of General Medicine ( IF 2.3 ) Pub Date : 2021-09-08 , DOI: 10.2147/ijgm.s330580 Nadeem Kassam 1 , Eric Aghan 2 , Omar Aziz 1 , Hanifa Mbithe 1 , Kamran Hameed 1 , Reena Shah 3 , Salim Surani 4 , James Orwa 5 , Samina Somji 1
International Journal of General Medicine ( IF 2.3 ) Pub Date : 2021-09-08 , DOI: 10.2147/ijgm.s330580 Nadeem Kassam 1 , Eric Aghan 2 , Omar Aziz 1 , Hanifa Mbithe 1 , Kamran Hameed 1 , Reena Shah 3 , Salim Surani 4 , James Orwa 5 , Samina Somji 1
Affiliation
Background: The emergence of the novel coronavirus disease 2019 (COVID-19) has caused millions of deaths worldwide. There has been paucity of data for hospitalized African patients suffering from COVID-19. This study aimed to identify factors associated with in-hospital mortality in patients suffering from COVID-19 in Tanzania.
Methods: This was a single center, retrospective, observational cohort study in adult patients hospitalized with confirmed COVID-19 infection. Demographics, clinical pattern, laboratory and radiological investigations associated with increased odds of mortality were analyzed.
Results: Of the 157 patients, 107 (68.1%) patients survived and 50 (31.8%) died. Mortality was highest in patients suffering with severe (26%) and critical (68%) forms of the disease. The median age of the cohort was 52 years (IQR 42– 61), majority of patients were male (86%) and of African origin (46%), who presented with fever (69%), cough (62%) and difficulty in breathing (43%). Factors that were associated with mortality among our cohort were advanced age (OR 1.07, 95% CI 1.03– 1.11), being overweight and obese (OR 9.44, 95% CI 2.71– 41.0), suffering with severe form of the disease (OR 4.77, 95% CI 1.18– 25.0) and being admitted to the HDU and ICU (OR 6.68, 95% CI 2.06– 24.6).
Conclusion: The overall in-hospital mortality was 31.8%. Older age, obesity, the severe form of the disease and admission to the ICU and HDU were major risk factors associated with in-hospital mortality.
中文翻译:
坦桑尼亚私立三级医院 COVID-19 肺炎住院成人死亡率的相关因素:一项回顾性队列研究
背景:新型冠状病毒病 2019 (COVID-19) 的出现已导致全球数百万人死亡。缺乏关于住院的非洲 COVID-19 患者的数据。本研究旨在确定与坦桑尼亚 COVID-19 患者住院死亡率相关的因素。
方法:这是一项针对确诊 COVID-19 感染住院的成年患者的单中心、回顾性、观察性队列研究。分析了与死亡率增加相关的人口统计学、临床模式、实验室和放射学调查。
结果:在 157 名患者中,107 名(68.1%)患者存活,50 名(31.8%)患者死亡。患有严重(26%)和严重(68%)疾病的患者死亡率最高。该队列的中位年龄为 52 岁(IQR 42-61),大多数患者为男性(86%)和非洲裔(46%),他们出现发烧(69%)、咳嗽(62%)和困难呼吸(43%)。在我们的队列中与死亡率相关的因素是高龄(OR 1.07, 95% CI 1.03–1.11)、超重和肥胖(OR 9.44, 95% CI 2.71–41.0)、患有严重疾病(OR 4.77 , 95% CI 1.18–25.0) 并入住 HDU 和 ICU (OR 6.68, 95% CI 2.06–24.6)。
结论:总体住院死亡率为31.8%。年龄较大、肥胖、疾病的严重形式以及入住 ICU 和 HDU 是与住院死亡率相关的主要危险因素。
更新日期:2021-09-08
Methods: This was a single center, retrospective, observational cohort study in adult patients hospitalized with confirmed COVID-19 infection. Demographics, clinical pattern, laboratory and radiological investigations associated with increased odds of mortality were analyzed.
Results: Of the 157 patients, 107 (68.1%) patients survived and 50 (31.8%) died. Mortality was highest in patients suffering with severe (26%) and critical (68%) forms of the disease. The median age of the cohort was 52 years (IQR 42– 61), majority of patients were male (86%) and of African origin (46%), who presented with fever (69%), cough (62%) and difficulty in breathing (43%). Factors that were associated with mortality among our cohort were advanced age (OR 1.07, 95% CI 1.03– 1.11), being overweight and obese (OR 9.44, 95% CI 2.71– 41.0), suffering with severe form of the disease (OR 4.77, 95% CI 1.18– 25.0) and being admitted to the HDU and ICU (OR 6.68, 95% CI 2.06– 24.6).
Conclusion: The overall in-hospital mortality was 31.8%. Older age, obesity, the severe form of the disease and admission to the ICU and HDU were major risk factors associated with in-hospital mortality.
中文翻译:
坦桑尼亚私立三级医院 COVID-19 肺炎住院成人死亡率的相关因素:一项回顾性队列研究
背景:新型冠状病毒病 2019 (COVID-19) 的出现已导致全球数百万人死亡。缺乏关于住院的非洲 COVID-19 患者的数据。本研究旨在确定与坦桑尼亚 COVID-19 患者住院死亡率相关的因素。
方法:这是一项针对确诊 COVID-19 感染住院的成年患者的单中心、回顾性、观察性队列研究。分析了与死亡率增加相关的人口统计学、临床模式、实验室和放射学调查。
结果:在 157 名患者中,107 名(68.1%)患者存活,50 名(31.8%)患者死亡。患有严重(26%)和严重(68%)疾病的患者死亡率最高。该队列的中位年龄为 52 岁(IQR 42-61),大多数患者为男性(86%)和非洲裔(46%),他们出现发烧(69%)、咳嗽(62%)和困难呼吸(43%)。在我们的队列中与死亡率相关的因素是高龄(OR 1.07, 95% CI 1.03–1.11)、超重和肥胖(OR 9.44, 95% CI 2.71–41.0)、患有严重疾病(OR 4.77 , 95% CI 1.18–25.0) 并入住 HDU 和 ICU (OR 6.68, 95% CI 2.06–24.6)。
结论:总体住院死亡率为31.8%。年龄较大、肥胖、疾病的严重形式以及入住 ICU 和 HDU 是与住院死亡率相关的主要危险因素。