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Dual-responsive ultrathin 1T-phase niobium telluride nanosheet-based delivery systems for enhanced chemo-photothermal therapy
Journal of Materials Chemistry B ( IF 7 ) Pub Date : 2021-09-08 , DOI: 10.1039/d1tb01469b
Hao Liu 1 , Haolin Chen 2 , Xiaoying Liu 3 , Luoqi Mo 1 , Chao Chen 1 , Zhouyi Guo 1 , Zhiming Liu 1
Affiliation  

1T-phase niobium telluride (NbTe2) nanosheets are becoming increasingly important in emerging fields, such as spintronics, sensors and magneto-optoelectronics, due to their excellent physical and chemical properties. However, exploration on their biomedical applications are limited. Herein, ultrathin 1T-phase NbTe2 single-crystalline nanosheets with excellent photothermal performance, high drug-loading rate, near-infrared (NIR) light/acidic pH-triggered drug release, and low toxicity were developed for potentiated photothermal therapy. Importantly, they showed excellent biocompatibility in vivo and in vitro. NbTe2 nanosheets loaded with integrated stress response inhibitors (ISRIB) could achieve chemo-photothermal therapy of tumors through the ATF4–ASNS signaling axis. Ultrathin 1T-phase NbTe2 single-crystalline nanosheets with unique photothermal properties, drug loading rate and safety provide dramatic possibilities in biomedical applications, such as tissue imaging, photothermal therapeutics and pharmaceutics.

中文翻译:

用于增强化学光热治疗的双响应超薄 1T 相碲化铌纳米片递送系统

1T相碲化铌(NbTe 2)纳米片由于其优异的物理和化学性质,在自旋电子学、传感器和磁光电子学等新兴领域变得越来越重要。然而,对其生物医学应用的探索是有限的。在此,开发了具有优异光热性能、高载药率、近红外 (NIR) 光/酸性 pH 触发药物释放和低毒性的超薄 1T 相 NbTe 2单晶纳米片,用于增强光热治疗。重要的是,它们在体内体外都表现出优异的生物相容性。NbTe 2载有综合应激反应抑制剂(ISRIB)的纳米片可以通过ATF4-ASNS信号轴实现肿瘤的化学光热治疗。具有独特光热特性、载药率和安全性的超薄 1T 相 NbTe 2单晶纳米片在组织成像、光热疗法和药剂学等生物医学应用中提供了巨大的可能性。
更新日期:2021-09-08
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