The production of reactive oxygen species, persistent inflammation, bacterial infection, and recurrence after a tumor resection has become the main challenge in cancer therapy and post-surgical skin regeneration. Herein, we report a multifunctional branched bioactive Si–Ca–P–Mo glass-ceramic nanoparticle (BBGN) with inlaid molybdate nanocrystals for an effective post-surgical melanoma therapy or infection therapy and defected skin reconstruction. Mixed-valence molybdenum (Mo⁴⁺ and Mo⁶⁺) doped BBGN (BBGN-Mo) was first synthesized via a hydrothermally assisted classical synthesis of BGN, which enables the structure with a lot of free electrons and oxygen vacancies. The BBGN-Mo exhibits excellent photothermal, antibacterial, enzyme-like radical scavenging, and anti-inflammatory as well as promoted vascularized efficiencies. BBGN-Mo could kill drug-resistant methicillin-resistant Staphylococcus aureus (MRSA) bacteria in vitro (99.5%) and in vivo (97.0%) at a low photothermal temperature (42 °C) and efficiently enhance the MRSA-infected wound repair. Additionally, BBGN-Mo could effectively inhibit tumor recurrence (96.4%), continuously improve the wound anti-inflammation and vascularization microenvironment, and significantly promote the post-surgical skin regeneration. This work suggests that conventional bioceramics could be turned to the highly efficient nanodrug for treating the challenge of post-surgical cancer therapy or infection therapy and tissue regeneration, through the mixed-valence strategy.

中文翻译：

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一种用于术后感染/癌症治疗-组织再生的多功能生物活性微晶玻璃纳米药物

活性氧的产生、持续的炎症、细菌感染和肿瘤切除后的复发已成为癌症治疗和术后皮肤再生的主要挑战。在此，我们报告了一种多功能分支生物活性 Si-Ca-P-Mo 玻璃陶瓷纳米颗粒 (BBGN)，其镶嵌有钼酸盐纳米晶体，可用于有效的手术后黑色素瘤治疗或感染治疗和缺损皮肤重建。混合价钼（Mo ⁴⁺和Mo ⁶⁺) 掺杂的 BBGN (BBGN-Mo) 最初是通过 BGN 的水热辅助经典合成合成的，这使得该结构具有大量自由电子和氧空位。BBGN-Mo 表现出优异的光热、抗菌、酶样自由基清除和抗炎以及促进血管化效率。BBGN-Mo 可在体外(99.5%) 和体内杀死耐药的耐甲氧西林金黄色葡萄球菌(MRSA) 细菌(97.0%) 在低光热温度 (42 °C) 下并有效增强 MRSA 感染的伤口修复。此外，BBGN-Mo可有效抑制肿瘤复发（96.4%），持续改善伤口抗炎和血管化微环境，显着促进术后皮肤再生。这项工作表明，通过混合价策略，可以将传统的生物陶瓷转化为高效的纳米药物，以应对手术后癌症治疗或感染治疗和组织再生的挑战。