Mortalin is involved in the malignant phenotype of many cancers. However, the specific molecular mechanisms involving Mortalin in lung adenocarcinoma remain unclear. In this study, we showed that both Mortalin mRNA and protein are overexpressed in lung adenocarcinoma. In addition, Mortalin overexpression was positively correlated with poor overall survival. In vitro experiments showed that Mortalin silencing inhibited the proliferation, colony formation and migration abilities of A549 and H1299 cells. Mortalin promotes EMT progression, angiogenesis and tumor progression by activating the Wnt/β-catenin signaling pathway. In vivo experiments further confirmed that Mortalin promoted malignant progression of lung adenocarcinoma. Taken together, our data suggest that Mortalin represents an attractive prognostic marker and therapeutic target in lung adenocarcinoma patients.

中文翻译：

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Mortalin 的预后价值与肺腺癌上皮-间质转化和血管生成中的作用相关。

Mortalin 与许多癌症的恶性表型有关。然而，Mortalin 在肺腺癌中的具体分子机制仍不清楚。在这项研究中，我们发现 Mortalin mRNA 和蛋白质在肺腺癌中均过表达。此外，Mortalin 过表达与较差的总体存活率呈正相关。体外实验表明，Mortalin 沉默抑制了 A549 和 H1299 细胞的增殖、集落形成和迁移能力。Mortalin 通过激活 Wnt/β-catenin 信号通路促进 EMT 进展、血管生成和肿瘤进展。体内实验进一步证实了 Mortalin 促进了肺腺癌的恶性进展。综合起来，