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Research Progress on the Mechanism of Cochlear Hair Cell Regeneration.
Frontiers in Cellular Neuroscience ( IF 5.3 ) Pub Date : 2021-08-20 , DOI: 10.3389/fncel.2021.732507 Shan Xu 1 , Ning Yang 1
Frontiers in Cellular Neuroscience ( IF 5.3 ) Pub Date : 2021-08-20 , DOI: 10.3389/fncel.2021.732507 Shan Xu 1 , Ning Yang 1
Affiliation
Mammalian inner ear hair cells do not have the ability to spontaneously regenerate, so their irreversible damage is the main cause of sensorineural hearing loss. The damage and loss of hair cells are mainly caused by factors such as aging, infection, genetic factors, hypoxia, autoimmune diseases, ototoxic drugs, or noise exposure. In recent years, research on the regeneration and functional recovery of mammalian auditory hair cells has attracted more and more attention in the field of auditory research. How to regenerate and protect hair cells or auditory neurons through biological methods and rebuild auditory circuits and functions are key scientific issues that need to be resolved in this field. This review mainly summarizes and discusses the recent research progress in gene therapy and molecular mechanisms related to hair cell regeneration in the field of sensorineural hearing loss.
中文翻译:
耳蜗毛细胞再生机制的研究进展。
哺乳动物内耳毛细胞不具有自发再生的能力,因此它们不可逆转的损伤是感音神经性听力损失的主要原因。毛细胞的损伤和丢失主要由衰老、感染、遗传因素、缺氧、自身免疫性疾病、耳毒性药物或噪声暴露等因素引起。近年来,哺乳动物听觉毛细胞再生和功能恢复的研究越来越受到听觉研究领域的关注。如何通过生物学方法再生和保护毛细胞或听觉神经元,重建听觉回路和功能,是该领域需要解决的关键科学问题。
更新日期:2021-08-20
中文翻译:
耳蜗毛细胞再生机制的研究进展。
哺乳动物内耳毛细胞不具有自发再生的能力,因此它们不可逆转的损伤是感音神经性听力损失的主要原因。毛细胞的损伤和丢失主要由衰老、感染、遗传因素、缺氧、自身免疫性疾病、耳毒性药物或噪声暴露等因素引起。近年来,哺乳动物听觉毛细胞再生和功能恢复的研究越来越受到听觉研究领域的关注。如何通过生物学方法再生和保护毛细胞或听觉神经元,重建听觉回路和功能,是该领域需要解决的关键科学问题。