Toward addressing many neuroprosthetic applications, the Neurochip3 (NC3) is a multichannel bidirectional brain-computer interface that operates autonomously and can support closed-loop activity-dependent stimulation. It consists of four circuit boards populated with off-the-shelf components and is sufficiently compact to be carried on the head of a non-human primate (NHP). NC3 has six main components: (1) an analog front-end with an Intan biophysical signal amplifier (16 differential or 32 single-ended channels) and a 3-axis accelerometer, (2) a digital control system comprised of a Cyclone V FPGA and Atmel SAM4 MCU, (3) a micro SD Card for 128 GB or more storage, (4) a 6-channel differential stimulator with ±60 V compliance, (5) a rechargeable battery pack supporting autonomous operation for up to 24 h and, (6) infrared transceiver and serial ports for communication. The NC3 and earlier versions have been successfully deployed in many closed-loop operations to induce synaptic plasticity and bridge lost biological connections, as well as deliver activity-dependent intracranial reinforcement. These paradigms to strengthen or replace impaired connections have many applications in neuroprosthetics and neurorehabilitation.

中文翻译：

---

Neurochip3：用于闭环活动依赖性刺激的自主多通道双向脑机接口。

为了解决许多神经假体应用，Neurochip3 (NC3) 是一种多通道双向脑机接口，可自主运行并支持闭环活动相关刺激。它由四个装有现成组件的电路板组成，并且足够紧凑，可以放在非人类灵长类动物 (NHP) 的头上。NC3 有六个主要组件：(1) 带有 Intan 生物物理信号放大器（16 个差分或 ​​32 个单端通道）和 3 轴加速度计的模拟前端，(2) 由 Cyclone V FPGA 组成的数字控制系统和 Atmel SAM4 MCU，(3) 一个用于 128 GB 或更多存储空间的微型 SD 卡，(4) 一个符合 ±60 V 标准的 6 通道差分刺激器，(5) 一个支持长达 24 小时自主运行的可充电电池组和, (6)红外收发器和串口进行通讯。NC3 和早期版本已成功部署在许多闭环操作中，以诱导突触可塑性和桥接失去的生物连接，以及提供依赖于活动的颅内强化。这些加强或替代受损连接的范例在神经假肢和神经康复中有许多应用。