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The Ubiquitin Sensor and Adaptor Protein p62 Mediates Signal Transduction of a Viral Oncogenic Pathway
mBio ( IF 6.4 ) Pub Date : 2021-09-07 , DOI: 10.1128/mbio.01097-21
Ling Wang 1, 2 , Mary E A Howell 1 , Ayrianna Sparks-Wallace 1 , Juan Zhao 1, 2 , Culton R Hensley 1 , Camri A Nicksic 1 , Shanna R Horne 1 , Kaylea B Mohr 1 , Jonathan P Moorman 1, 2, 3 , Zhi Q Yao 1, 2, 3 , Shunbin Ning 1, 2
Affiliation  

As a ubiquitin sensor and a signal-transducing adaptor, p62 is crucial for NF-κB activation, which involves the ubiquitin machinery in diverse contexts. However, whether p62 is required for EBV LMP1 activation of NF-κB is an open question.

中文翻译:

泛素传感器和衔接蛋白 p62 介导病毒致癌途径的信号转导

作为泛素传感器和信号转导适配器,p62 对于 NF-κB 激活至关重要,这涉及不同环境中的泛素机制。然而,EBV LMP1 激活 NF-κB 是否需要 p62 是一个悬而未决的问题。
更新日期:2021-09-12
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