Soft materials, such as hydrogels, are used as scaffolds in tissue engineering and regenerative medicine to help tissues regenerate and heal. Recently, supramolecular hydrogels, based on non-covalent interactions, have grown in popularity, especially in the development of materials for biomedical use. Their potential lies in the dynamic, reversible and temporary nature of their crosslinks, which can make them responsive to stimuli, injectable and suitable for 3D printing. Such versatility and processability is important when developing new biomaterials for drug delivery or as implantable scaffolds. The behavior and properties of such hydrogels are different compared to those of chemically crosslinked hydrogels. In this review, we give an overview on supramolecular hydrogels which contain hyaluronic acid (HA) as one of the building blocks. HA is particularly interesting, due to its hydrophilicity, biofunctionality and ease of chemical modification. Specifically, we focus on HA-based hydrogels that make use of hydrogen bonding, hydrophobic interactions, electrostatic interactions, metal–ion coordination and guest–host interactions, and are intended for applications in the biomedical field, with potential for clinical translation.

软材料，如水凝胶，在组织工程和再生医学中用作支架，帮助组织再生和愈合。最近，基于非共价相互作用的超分子水凝胶越来越受欢迎，尤其是在生物医学材料的开发中。它们的潜力在于其交联的动态、可逆和临时性质，这可以使它们对刺激做出反应、可注射并适用于 3D 打印。在开发用于药物输送或作为可植入支架的新生物材料时，这种多功能性和可加工性非常重要。与化学交联的水凝胶相比，这种水凝胶的行为和性质是不同的。在这篇综述中，我们概述了含有透明质酸 (HA) 作为构建块之一的超分子水凝胶。HA 特别令人感兴趣，因为它具有亲水性、生物功能性和易于化学修饰。具体而言，我们专注于利用氢键、疏水相互作用、静电相互作用、金属-离子配位和客体-宿主相互作用的基于 HA 的水凝胶，旨在用于生物医学领域，具有临床转化潜力。