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Application of green synthesized silver nanoparticles in cancer treatment—a critical review
Materials Research Express ( IF 2.3 ) Pub Date : 2021-09-03 , DOI: 10.1088/2053-1591/ac1de3
Shazina Jabeen 1 , Rahmatullah Qureshi 1 , Mehmooda Munazir 2 , Muhammad Maqsood 1 , Mubashrah Munir 3 , Syed Sabir Hussain Shah 1 , Bakht Zareen Rahim 4
Affiliation  

With the breakthrough in advance technologies, researchers are looking to devise novel approaches to control different types of deadly cancers. Progress in medicinal plants research and nanotechnology has drawn scientist’s attention toward green synthesis of metallic nanoparticles by exploiting plants secondary metabolites owing to its advantage over routinely used physical and chemical synthesis (simple, one step approach to reduce and stabilize bulk silver into silver nanoparticles (AgNPs), cost effectiveness, energy efficient, biocompatibility and therapeutic significance). Owing to control size, shape and functional surface corona, AgNPs hold considerable potentiality for therapeutic applications by opting different mechanistic pathways such as mitochondrial disruption, DNA fragmentation, cell membrane disruption, interruption of cellular signaling pathways, altered enzyme activity and reactive oxygen species (ROS) production leading to apoptosis etc In this review, we discussed the green synthesized AgNPs in the possible cancer treatment by harnessing phytochemicals present in plant extract. In addition, this review also provides recent advances and achievements in utilization of green synthesized AgNPs in cancer treatment and proposes mechanistic action for their anticancer and cytotoxic potential. By understanding the mechanistic action of AgNPs responsible for their therapeutic efficacy will help to devise customized therapies and treatment against cancer as a potential cancer therapeutic tool.



中文翻译:

绿色合成银纳米粒子在癌症治疗中的应用——批判性评论

随着先进技术的突破,研究人员正在寻求设计新方法来控制不同类型的致命癌症。药用植物研究和纳米技术的进展吸引了科学家对通过利用植物次级代谢产物绿色合成金属纳米粒子的关注,因为它优于常规使用的物理和化学合成(简单的一步法将大量银还原和稳定成银纳米粒子(AgNPs) )、成本效益、节能、生物相容性和治疗意义)。由于控制大小、形状和功能表面电晕,AgNPs 通过选择不同的机制途径,如线粒体破坏、DNA 断裂、细胞膜破坏、细胞信号通路中断、酶活性改变和活性氧 (ROS) 产生导致细胞凋亡等 在这篇综述中,我们讨论了绿色合成的 AgNPs 通过利用植物提取物中存在的植物化学物质在可能的癌症治疗中的作用。此外,本综述还提供了利用绿色合成的 AgNPs 在癌症治疗中的最新进展和成就,并提出了其抗癌和细胞毒性潜力的机制作用。通过了解负责其治疗功效的 AgNPs 的机械作用,将有助于设计针对癌症的定制疗法和治疗方法,作为潜在的癌症治疗工具。我们通过利用植物提取物中存在的植物化学物质讨论了绿色合成的 AgNPs 在可能的癌症治疗中的作用。此外,本综述还提供了利用绿色合成的 AgNPs 在癌症治疗中的最新进展和成就,并提出了其抗癌和细胞毒性潜力的机制作用。通过了解负责其治疗功效的 AgNPs 的机械作用,将有助于设计针对癌症的定制疗法和治疗方法,作为潜在的癌症治疗工具。我们通过利用植物提取物中存在的植物化学物质讨论了绿色合成的 AgNPs 在可能的癌症治疗中的作用。此外,本综述还提供了利用绿色合成的 AgNPs 在癌症治疗中的最新进展和成就,并提出了其抗癌和细胞毒性潜力的机制作用。通过了解负责其治疗功效的 AgNPs 的机械作用,将有助于设计针对癌症的定制疗法和治疗方法,作为潜在的癌症治疗工具。

更新日期:2021-09-03
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