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Tailored Functionalization of Natural Phenols to Improve Biological Activity
Biomolecules ( IF 5.5 ) Pub Date : 2021-09-07 , DOI: 10.3390/biom11091325 Barbara Floris 1 , Pierluca Galloni 1 , Valeria Conte 1 , Federica Sabuzi 1
Biomolecules ( IF 5.5 ) Pub Date : 2021-09-07 , DOI: 10.3390/biom11091325 Barbara Floris 1 , Pierluca Galloni 1 , Valeria Conte 1 , Federica Sabuzi 1
Affiliation
Phenols are widespread in nature, being the major components of several plants and essential oils. Natural phenols’ anti-microbial, anti-bacterial, anti-oxidant, pharmacological and nutritional properties are, nowadays, well established. Hence, given their peculiar biological role, numerous studies are currently ongoing to overcome their limitations, as well as to enhance their activity. In this review, the functionalization of selected natural phenols is critically examined, mainly highlighting their improved bioactivity after the proper chemical transformations. In particular, functionalization of the most abundant naturally occurring monophenols, diphenols, lipidic phenols, phenolic acids, polyphenols and curcumin derivatives is explored.
中文翻译:
天然酚的定制功能化以提高生物活性
苯酚在自然界中广泛存在,是多种植物和精油的主要成分。如今,天然酚的抗微生物、抗菌、抗氧化、药理和营养特性已得到充分证实。因此,鉴于其独特的生物学作用,目前正在进行大量研究以克服其局限性并增强其活性。在这篇综述中,对选定的天然酚的功能化进行了严格的检查,主要强调了它们在适当的化学转化后生物活性的提高。特别是,探索了最丰富的天然存在的单酚、二酚、脂酚、酚酸、多酚和姜黄素衍生物的功能化。
更新日期:2021-09-07
中文翻译:
天然酚的定制功能化以提高生物活性
苯酚在自然界中广泛存在,是多种植物和精油的主要成分。如今,天然酚的抗微生物、抗菌、抗氧化、药理和营养特性已得到充分证实。因此,鉴于其独特的生物学作用,目前正在进行大量研究以克服其局限性并增强其活性。在这篇综述中,对选定的天然酚的功能化进行了严格的检查,主要强调了它们在适当的化学转化后生物活性的提高。特别是,探索了最丰富的天然存在的单酚、二酚、脂酚、酚酸、多酚和姜黄素衍生物的功能化。