ABSTRACT

Background

The clinical value of indocyanine green (ICG) in laparoscopic radical gastrectomy remains controversial. We performed this meta-analysis to investigate the safety and efficacy of ICG fluorescence imaging-guided radical gastrectomy.

Methods

All relevant studies published until 30 October 2020 were retrieved from several databases. Fixed- and random-effects models were used to analyze the results based on different heterogeneity levels. Data were expressed as odds ratios or weighted mean differences along with 95% confidence intervals. The Grading of Recommendations, Assessment, Development, and Evaluation system scale was used for quality of evidence evaluation.

Results

This meta-analysis included six cohort studies that investigated 622 patients. Compared with conventional radical gastrectomy, ICG fluorescence imaging-guided gastrectomy facilitates complete lymph node dissection, reduces intraoperative blood loss, and shortens the length of postoperative hospitalization. Moreover, we observed no significant intergroup differences in the operative time, first exhaust time, and postoperative complications.

Conclusion

ICG fluorescence imaging-guided radical gastrectomy scores over conventional gastrectomy and appears to be a promising approach in patients who require radical gastrectomy. However, further research is warranted to explore the potential long-term survival benefit of ICG fluorescence imaging in patients with gastric cancer.

中文翻译：

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吲哚菁绿荧光成像引导的根治性胃切除术的安全性和有效性：系统评价和荟萃分析

摘要

背景

吲哚菁绿（ICG）在腹腔镜胃癌根治术中的临床价值仍存在争议。我们进行了这项荟萃分析，以研究 ICG 荧光成像引导的根治性胃切除术的安全性和有效性。

方法

从多个数据库检索到截至 2020 年 10 月 30 日发表的所有相关研究。使用固定和随机效应模型来分析基于不同异质性水平的结果。数据表示为优势比或加权平均差以及 95% 置信区间。建议分级、评估、开发和评估系统量表用于证据质量评估。

结果

这项荟萃分析包括六项队列研究，调查了 622 名患者。与传统的根治性胃切除术相比，ICG荧光成像引导的胃切除术有利于彻底清扫淋巴结，减少术中失血，缩短术后住院时间。此外，我们观察到在手术时间、首次排气时间和术后并发症方面没有显着的组间差异。

结论

ICG 荧光成像引导的根治性胃切除术评分优于传统的胃切除术，似乎是需要根治性胃切除术的患者的一种有前途的方法。然而，需要进一步的研究来探索 ICG 荧光成像对胃癌患者的潜在长期生存益处。