Abstract

Amberlyst 15 (A-15) is one of the most common heterogeneous catalysts in organic synthesis. Since its development in 1962, A-15 has proved to be a highly efficient green catalyst in many organic reactions that require acid catalysis. In the last two decades, many reports had been issued that focused on the use of A-15 as a catalyst in heterocyclic synthesis. The use of A-15 implies many advantages as being inexpensive, non-toxic, easily handled, and easily separable from the reaction mixture. Other advantages include easy separation of the products and the recyclability. The latter is highly useful in sustainable chemistry. The present review summarizes the applications of Amberlyst 15 as a green catalyst in the synthesis of heterocycles during the last decade (from 2010 till 2019). The review is classified according to the ring size with a focus on the mechanism of reactions catalyzed by A-15.

中文翻译：

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Amberlyst 15®：一种用于合成杂环化合物的高效绿色催化剂

摘要

Amberlyst 15 (A-15) 是有机合成中最常见的多相催化剂之一。自 1962 年开发以来，A-15 已被证明在许多需要酸催化的有机反应中是一种高效的绿色催化剂。在过去的 20 年中，发表了许多关于 A-15 在杂环合成中用作催化剂的报告。A-15 的使用意味着许多优点，如廉价、无毒、易于处理和易于从反应混合物中分离。其他优点包括产品易于分离和可回收。后者在可持续化学中非常有用。本综述总结了过去十年（2010 年至 2019 年）Amberlyst 15 作为绿色催化剂在杂环合成中的应用。