According to the reconsolidation theory, memories can be modified through the destabilization-reconsolidation process. The rodent perirhinal cortex (PER; Brodmann areas 35 and 36) critically participates in the process of fear conditioning. Previous studies showed that some of the parahippocampal regions are critical for contextual fear memory reconsolidation. In our research, through a three-day paradigm of CFC, we showed that protein synthesis in PER of rats is required for memory reconsolidation, and activation of CB1 pathway is necessary but not sufficient in inducing memory destabilization. This result underlines parahippocampal regions in destabilization and reconsolidation process of fear memory besides amygdala and hippocampus.

根据重新整合理论，记忆可以通过不稳定-重新整合过程进行修改。啮齿动物鼻周皮层（PER；布罗德曼35 和 36 区）严重参与了恐惧条件反射的过程。以前的研究表明，一些海马旁区域对于情境恐惧记忆的重新巩固至关重要。在我们的研究中，通过为期三天的 CFC 范例，我们发现大鼠 PER 中的蛋白质合成是记忆重新巩固所必需的，而 CB1 通路的激活是诱导记忆不稳定的必要条件，但还不够。这一结果强调了除杏仁核和海马外，恐惧记忆的不稳定和重新巩固过程中的海马旁区域。