The cell membrane, with high fluidity and alternative curvatures, maintains the robust integrity to distinguish inner and outer space of cells or organelles. Lipids are the main components of the cell membrane, but their functions are largely unknown. Even the visualization of lipids is not straightforward since modification of lipids often hampers its correct physical properties. Many natural products target cell membranes, some of which are used as pharmaceuticals and/or research tools. They show specific recognition on lipids, and thus exhibit desired pharmacological effects and unique biological phenotypes. This review is a catalog of marine natural products that target eukaryotic cell membranes. Chemical structures, biological activities, and molecular mechanisms are summarized. I hope that this review will be helpful for readers to notice the potential of marine natural products in the exploration of the function of lipids and the druggability of eukaryotic cell membranes.

具有高流动性和交替曲率的细胞膜保持了强大的完整性，以区分细胞或细胞器的内部和外部空间。脂质是细胞膜的主要成分，但它们的功能在很大程度上是未知的。甚至脂质的可视化也不是直接的，因为脂质的修饰通常会妨碍其正确的物理特性。许多天然产品靶向细胞膜，其中一些用作药物和/或研究工具。它们显示出对脂质的特异性识别，因此表现出所需的药理作用和独特的生物表型。这篇综述是一份针对真核细胞膜的海洋天然产品目录。总结了化学结构、生物活性和分子机制。