Lay Summary

• Platinum-containing chemotherapy is often used to treat children with cancer.
• Although it is a very effective medication, unfortunately, it causes permanent hearing loss in more than one-half of the children who receive it.
• In this issue of Cancer, an article by Meijer and colleagues shows that very young children are affected early on in their treatment and suggests that the younger the child the more frequently their hearing should be tested during treatment.
• This proposal is a real challenge for oncology centers and families practically, emotionally, and socioeconomically.
• The findings are provocative but equally stimulating and encouraging; hopefully, they will lead to a new standard of multidisciplinary care for children receiving platinum chemotherapy.

中文翻译：

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对顺铂耳毒性的新见解

总结

• 含铂化学疗法通常用于治疗患有癌症的儿童。
• 虽然它是一种非常有效的药物，但不幸的是，它会导致超过一半的儿童永久性听力丧失。
• 在本期Cancer中，Meijer 及其同事的一篇文章表明，非常年幼的孩子在治疗的早期就会受到影响，并建议孩子越小，在治疗期间应该更频繁地测试他们的听力。
• 该提案在实践、情感和社会经济方面对肿瘤中心和家庭来说都是一个真正的挑战。
• 这些发现具有启发性，但同样令人振奋和鼓舞；希望它们能为接受铂类化疗的儿童带来新的多学科护理标准。