Pyrotinib is an irreversible EGFR/HER2 inhibitor that has shown antitumor activity and tolerance in the treatment of breast cancer. Studies focused on its metabolic pathways and major metabolites are insufficient. In the evaluation of drug safety and therapeutic use, metabolite characterization is critical. The metabolism of pyrotinib in vitro was studied utilizing rat, dog and human hepatocytes in this study.

中文翻译：

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使用液相色谱-四极杆/轨道阱质谱法通过大鼠、狗和人类肝细胞对吡咯替尼进行体外代谢物分析

Pyrotinib 是一种不可逆的 EGFR/HER2 抑制剂，在乳腺癌治疗中显示出抗肿瘤活性和耐受性。专注于其代谢途径和主要代谢物的研究不足。在评估药物安全性和治疗用途时，代谢物表征至关重要。在本研究中，利用大鼠、狗和人类肝细胞研究了吡咯替尼的体外代谢。