Pulmonary Benefits of Intervention with Air Cleaner among Schoolchildren in Beijing: A Randomized Double-Blind Crossover Study,Environmental Science & Technology

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Pulmonary Benefits of Intervention with Air Cleaner among Schoolchildren in Beijing: A Randomized Double-Blind Crossover Study
Environmental Science & Technology ( IF 11.4 ) Pub Date : 2021-09-07 , DOI: 10.1021/acs.est.1c03146
Xiaoyan Yang _{1,

2} , Qin Wang _{1,

3} , Feng Han ₄ , Bin Dong ₅ , Bo Wen ₅ , Li Li _{1,

2} , Hongjie Ruan _{1,

2} , Shaoping Zhang _{1,

2} , Jian Kong _{1,

2} , Hong Zhi _{1,

2} , Chong Wang _{1,

2} , Jun Wang _{1,

6} , Ming Zhang _{1,

2} , Dongqun Xu ₁

Affiliation

We conducted a crossover study employing air cleaner intervention among 125 schoolchildren aged 9–12 years in a boarding school in Beijing, China. The PM concentrations were monitored, and 27 biomarkers were analyzed. We used the linear mixed-effects model to evaluate the association of intervention/time-weighted PM concentrations with biomarkers. The outcomes showed that air cleaner intervention was associated with FeNO, exhaled breath condensate (EBC) IL-1β, and IL-6, which decreased by 12.57%, 10.83%, and 4.33%, respectively. Similar results were observed in the associations with PMs. Lag 1 day PMs had the strongest relationship with biomarkers, and significant changes were observed in biomarkers such as FEV₁, FeNO, EBC 8-iso, and MCP-1. Boys showed higher percentage changes than girls, and the related biomarkers were FeNO, EBC 4-HNE, IL-1β, IL-6, and MCP-1. The results showed that biomarkers such as FeNO, EBC IL-6, MCP-1, and 4-HNE could sensitively reflect the early abnormal response of the respiratory system under short-term PM exposure among healthy schoolchildren and indicated that (1) air cleaners exert a protective effect on children’s respiratory system. (2) PM had lag and cumulative effect, lag 1 day had the greatest effect. (3) The boys were more sensitive than the girls.

更新日期：2021-09-07

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