A novel method for the synthesis of 3-monohalooxindoles by acidolysis of isatin-derived 3-phosphate-substituted oxindoles with haloid acids was developed. This synthetic strategy involved the preparation of 3-phosphate-substituted oxindole intermediates and S_N1 reactions with haloid acids. This new procedure features mild reaction conditions, simple operation, good yield, readily available and inexpensive starting materials, and gram-scalability.

中文翻译：

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一种通过用卤酸酸解 3-磷酸取代的羟吲哚有效合成 3-单卤代吲哚的新方法

开发了一种通过用卤代酸酸解靛红衍生的 3-磷酸取代 oxindoles 来合成 3-monohalooxindoles 的新方法。该合成策略涉及制备 3-磷酸取代的羟吲哚中间体以及与卤酸的S _N 1 反应。该新工艺具有反应条件温和、操作简单、收率好、原料易得且价格低廉、克级规模化等特点。