To this day, the identity of gonadotropin-releasing hormone (GnRH) progenitors remains unclear. However, the visualization of different developmental markers in subsets of GnRH neurons during early embryonic stages raised the possibility of at least two GnRH subpopulations. This observation led directly to a second question. Does visualization of different developmental markers in subsets of GnRH neurons reflect functional heterogeneity? This question remains unanswered, but as we learn more about the GnRH system, functional GnRH subpopulations become critically important to understanding GnRH function. This review addresses the development of the neuroendocrine GnRH system, specifically the heterogeneity of the GnRH neuroendocrine population.

中文翻译：

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解读促性腺激素释放激素神经内分泌细胞谱系的隐藏“陷阱”

迄今为止，促性腺激素释放激素 (GnRH) 祖细胞的身份仍不清楚。然而，早期胚胎阶段 GnRH 神经元亚群中不同发育标志物的可视化提高了至少两个 GnRH 亚群的可能性。这一观察直接引出了第二个问题。GnRH 神经元亚群中不同发育标志物的可视化是否反映了功能异质性？这个问题仍未得到解答，但随着我们更多地了解 GnRH 系统，功能性 GnRH 亚群对于理解 GnRH 功能变得至关重要。本综述探讨了神经内分泌 GnRH 系统的发展，特别是 GnRH 神经内分泌群体的异质性。