The Front Cover shows a monofluorinated spiro[3.3]heptane scaffold – A promising chemotype for medicinal chemistry. The picture highlights its most interesting feature, which is axial chirality. To achieve this, the background photo has been made by putting the molecular model in front of a mirror. Additional features of the title scaffold are revealed, i.e., lower lipophilicity and a higher propensity to generate lead-like chemical space as compared to non- or difluorinated analogs. The authors thank Mr. Bohdan V. Vashchenko for his invaluable help with the artwork preparation. More information can be found in the Full Paper by O. O. Grygorenko et al.

中文翻译：

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封面：氟标记的螺[3.3]庚烷衍生的构件：单一氟是最好的吗？(Eur. J. Org. Chem. 35/2021)

封面展示了一种单氟化螺[3.3]庚烷支架——一种很有前途的药物化学化学型。该图突出了其最有趣的特征，即轴向手性。为了实现这一点，背景照片是通过将分子模型放在镜子前制作的。揭示了标题支架的其他特征，即与非或二氟化类似物相比，更低的亲脂性和更高的产生铅样化学空间的倾向。作者感谢 Bohdan V. Vashchenko 先生在艺术品准备方面提供的宝贵帮助。更多信息可以在 OO Grygorenko 等人的全文中找到。