Owing to the advantages offered by fluorine in the pharmaceutical and agrochemical industry, methods to incorporate fluorine have gained immense attention in the last two decades. Recently, several sustainable catalysts based on first row transition metals have been employed for fluoromethylation reactions. Amongst them, nickel catalysts due to their abundance, less toxicity and high catalytic activity have been increasingly used for the introduction of a variety of fluorinated functionalities like mono-, di- and tri-fluoromethyl groups including trifluoromethyl selenides and sulfides. This is the first review that exclusively covers the important strategies and mechanistic analyses in nickel-catalysed mono-, di- and tri-fluoromethylation, trifluoromethylthiolation and trifluoromethylselenolation covering the literature up to 2021.

中文翻译：

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镍催化的氟甲基化反应

由于氟在制药和农业化学工业中的优势，在过去的二十年中，掺入氟的方法受到了极大的关注。最近，几种基于第一排过渡金属的可持续催化剂已用于氟甲基化反应。其中，镍催化剂因其丰富、毒性小和催化活性高而越来越多地用于引入各种氟化官能团，如单、二和三氟甲基，包括三氟甲基硒化物和硫化物。这是第一篇专门涵盖镍催化的单、二和三氟甲基化、三氟甲基硫醇化和三氟甲基硒化的重要策略和机理分析的综述，涵盖了截至 2021 年的文献。