The present retrospective cohort study examines whether there is an association between circulating nucleated red blood cells (nRBCs) and mortality in critically ill children. nRBCs are erythropoietic progenitor cells not found in peripheral blood of healthy adults and children beyond the neonatal period. The presence of circulating nRBCs is associated with poor prognosis in adults and neonates, though little is known about their significance in children. Admissions to both the general and cardiac pediatric intensive care unit at the Stollery Children's Hospital in Edmonton, Alberta between January 1, 2015 and December 31, 2017 were examined, and logistic regression was performed to ascertain the association between the peak absolute nRBC counts and in-hospital mortality in critically ill children. A total of 2065 admissions were included. The number of admissions with detectable nRBCs was 386 (prevalence: 13.9%), and the number of deaths was 93 (mortality: 4.5%). A statistically significant association was found between the absolute value of nRBC peak and intensive care unit mortality (odds ratio=1.37; 95% confidence interval: 1.13-1.67; P=0.002) as well as hospital mortality (odds ratio=1.38; 95% confidence interval: 1.12-1.70; P=0.003) independent of the Pediatric Index of Mortality 3 score (PIM3). This result warrants more attention to nRBC values and their potential clinical use.

中文翻译：

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危重儿童外周有核红细胞和死亡率。

本回顾性队列研究检查了循环有核红细胞 (nRBC) 与重症儿童死亡率之间是否存在关联。nRBC 是在健康成人和新生儿期后儿童的外周血中未发现的红细胞生成祖细胞。循环 nRBC 的存在与成人和新生儿的不良预后相关，但对其在儿童中的意义知之甚少。对 2015 年 1 月 1 日至 2017 年 12 月 31 日期间艾伯塔省埃德蒙顿 Stollery 儿童医院普通科和心脏儿科重症监护病房的入院情况进行了检查，并进行了逻辑回归以确定峰值绝对 nRBC 计数与-危重儿童的住院死亡率。共计 2065 人入院。可检测到 nRBC 的入院人数为 386 人（患病率：13.9%），死亡人数为 93 人（死亡率：4.5%）。nRBC 峰值的绝对值与重症监护病房死亡率（比值比=1.37；95% 置信区间：1.13-1.67；P=0.002）以及住院死亡率（比值比=1.38；95%）之间存在统计学显着关联置信区间：1.12-1.70；P=0.003) 独立于儿科死亡率指数 3 评分 (PIM3)。这一结果值得更多关注 nRBC 值及其潜在的临床用途。P=0.002) 以及住院死亡率（比值比=1.38；95% 置信区间：1.12-1.70；P=0.003）与儿科死亡率指数 3 评分 (PIM3) 无关。这一结果值得更多关注 nRBC 值及其潜在的临床用途。P=0.002) 以及住院死亡率（比值比=1.38；95% 置信区间：1.12-1.70；P=0.003）与儿科死亡率指数 3 评分 (PIM3) 无关。这一结果值得更多关注 nRBC 值及其潜在的临床用途。