Abstract

In this work synthesis, characterization and crystal structures of 1, Zn(II) complex ([ZnL¹(NCS)₂]), with (E)-1-(2-oxo-2-(2-(quinolin-2-ylmethylene)hydrazinyl)ethyl)pyridin-1-ium chloride (HL¹Cl) and 2, Bi(III) complex ([BiHL²Cl₄] × 1/2CH₃OH), with (E)-N,N,N-trimethyl-2-oxo-2-(2-(1-(thiazol-2-yl)ethylidene)hydrazinyl)ethan-1-aminium chloride (HL²Cl), have been reported. Zn(II) complex possesses a distorted trigonal bipyramidal geometry while surroundings around Bi(III) ion are extended pentagonal bipyramidal. Antimicrobial activity, brine shrimp assay and DPPH radical scavenging activity of both complexes, including previously synthesized complexes with HL²Cl ligand (Zn(II) and Ni(II)) and complexes with (E)-N,N,N-trimethyl-2-oxo-2-(2-(1-(pyridin-2-yl)ethylidene)hydrazinyl)ethan-1-aminium chloride (HL³Cl) (Zn(II), Cu(II), Cd(II), Co(II), Fe(III), Ni(II)), were evaluated. For the most active complexes, cytotoxic activity against five malignant cancer cell lines (HeLa, A375, MCF7, PC-3 and A549) and normal cell line HaCaT, as well as generation of reactive oxygen species (ROS), was tested.

Graphic abstract

中文翻译：

---

d-金属与 Girard's T 和 P 试剂腙的合成、表征、抗菌和细胞毒活性以及 DNA 结合特性

摘要

在这项工作中合成、表征和晶体结构1 , Zn(II) 配合物 ([Zn L ¹ (NCS) ₂ ]), 与 ( E )-1-(2-oxo-2-(2-(quinolin-2) -基亚甲基)肼基)乙基)吡啶-1-氯化铵 ( HL ¹ Cl) 和2 , Bi(III) 络合物 ([Bi HL ² Cl ₄ ] × 1/2CH ₃ OH), 与 ( E )- N , N , N -trimethyl-2-oxo-2-(2-(1-(thiazol-2-yl)ethylidene)hydrazinyl)ethan-1-aminium chloride ( HL ²Cl), 已被报道。Zn(II) 配合物具有扭曲的三角双锥几何形状，而 Bi(III) 离子周围的环境是延伸的五角双锥。两种复合物的抗菌活性、盐水虾测定和 DPPH 自由基清除活性，包括先前合成的与HL ² Cl 配体（Zn(II) 和 Ni(II)）的复合物和与 ( E ) -N、N、N-三甲基- 2-氧代-2-(2-(1-(吡啶-2-基)亚乙基)肼基)乙烷-1-氯化铵( HL ³Cl) (Zn(II)、Cu(II)、Cd(II)、Co(II)、Fe(III)、Ni(II)) 进行了评估。对于最活跃的复合物，测试了对五种恶性癌细胞系（HeLa、A375、MCF7、PC-3 和 A549）和正常细胞系 HaCaT 的细胞毒活性，以及​​活性氧 (ROS) 的产生。

图形摘要