The overuse of antibiotics increases resistant bacteria, and their accumulation in the human body resulting in a pernicious influence or allergic effect on human health. As antibiotics have been used in livestock, their residue in food products is a serious problem. Therefore, the determination of tetracycline (TC) – an antibiotic in food samples by a simple, highly sensitive technique is necessary. This report presents a fluorescence sensor to detect TC based on fluorescence quenching by inner filter effect (IFE) between TC and Cs₄PbBr₆/CsPbBr₃ perovskite material. Cs₄PbBr₆/CsPbBr₃ acts as a fluorescence source with high luminescence quantum yield, narrow emission peak, and short radiative lifetime. It is also protected by perofluorooctyltriethyloxylsilane fluorocarbons assembled on the particle surface to form a water-resistance layer due to the high hydrophobic groups, –CF₂– and –CF₃, resulting in high aqueous dispersion. Under optimized conditions, the proposed sensor showed high sensitivity and selectivity to detect TC in food samples. The limit of detection is calculated as 76 nM with a linear range of 0.4 – 10 µM. The fluorescence quenching mechanism is assigned to IFE based on the excitation spectrum of Cs₄PbBr₆/CsPbBr₃ and the absorption spectrum of TC, as well as the compensatory fluorescence intensity of Cs₄PbBr₆/CsPbBr₃ with the energy absorbed by TC concentration.

过度使用抗生素会增加耐药菌，并在人体内积累，从而对人体健康产生有害影响或过敏反应。由于抗生素已用于牲畜，它们在食品中的残留是一个严重的问题。因此，通过简单、高灵敏度的技术测定食品样品中的抗生素四环素 (TC) 是必要的。本报告介绍了一种荧光传感器，该传感器基于 TC 和 Cs ₄ PbBr ₆ /CsPbBr ₃钙钛矿材料之间的内部过滤效应 (IFE) 的荧光猝灭来检测 TC 。Cs ₄ PbBr ₆ /CsPbBr ₃作为荧光源，发光量子产率高，发射峰窄，辐射寿命短。由于高疏水基团–CF ₂ – 和–CF ₃，它还受到组装在颗粒表面的全氟辛基三乙氧基硅烷氟碳化合物的保护，从而形成防水层，从而产生高水分散性。在优化条件下，所提出的传感器显示出检测食品样品中 TC 的高灵敏度和选择性。检测限计算为 76 nM，线性范围为 0.4 – 10 µM。基于Cs ₄ PbBr ₆ /CsPbBr ₃的激发光谱，将荧光猝灭机制归于IFE和TC的吸收光谱，以及Cs ₄ PbBr ₆ /CsPbBr ₃的补偿荧光强度与TC浓度吸收的能量。