Currently, no dressings utilized in burn clinics provide adhesion, hydration or mechanical strength on the same order as human skin as well as the ability to be atraumatically removed. We report the synthesis, characterization, and in vivo evaluation of in situ polymerized and subsequent dissolvable hydrogels as burn wound dressings. Hydrogel dressings, from a small library of synthesized materials form in situ, exhibit storage moduli between 100–40 000 Pa, dissolve on-demand within 10 minutes to 90 minutes, swell up to 350%, and adhere to both burned and healthy human skin at 0.2–0.3 N cm⁻². Further, results from an in vivo porcine second degree burn model demonstrate functional performance with healing equivalent to conventional treatments with the added benefit of facile, in situ application and subsequent removal via dissolution.

中文翻译：

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原位胶凝和可溶解水凝胶用作烧伤按需伤口敷料

目前，烧伤诊所使用的敷料还没有提供与人类皮肤相同的粘附力、水合作用或机械强度以及无创伤去除的能力。我们报告了原位聚合和随后可溶解水凝胶作为烧伤伤口敷料的合成、表征和体内评估。水凝胶敷料由原位形成的小型合成材料库制成，储能模量在 100–40 000 Pa 之间，在 10 分钟到 90 分钟内按需溶解，膨胀高达 350%，并粘附在烧伤和健康的人体皮肤上0.2–0.3 N cm ^-2。此外，体内猪二度烧伤模型的结果表明，其愈合功能性能与传统治疗相当，并具有简便的原位应用和随后通过溶解去除的附加优点。