Chitosan is a polysaccharide made up of β1,4-linked d-glucosamine (GlcN) and N-acetyl-GlcN. In this study, we evaluated the possible caloric restriction mimetic (CRM) effect of dietary chitosan on systemic redox status, inflammatory biomarkers, and lipid profile in plasma and erythrocyte samples of d-galactose-induced mimetically aged rats. We found a significant increase (p < 0.05) in the reactive oxygen species, protein carbonyl, fasting glucose, body weight, cholesterol, triglyceride, inflammatory markers—interleukin-6 and tumor necrosis factor-alpha in an accelerated senescent rat model. There was also a significant decrease (p < 0.05) in glutathione, advanced glycation end product in senescent rats. Chitosan treatment increased ferric-reducing antioxidant potential, glutathione, plasma membrane-reduced system in accelerated senescent model of rats. Our finding suggests that chitosan has properties similar to a CRM and can effectively maintain the redox homeostasis during the aging process in rat erythrocytes.

中文翻译：

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壳聚糖在衰老大鼠中显示出有效的热量限制模拟作用

壳聚糖是一种多糖，由 β1,4-连接的d-葡糖胺 (GlcN) 和N-乙酰基-GlcN 组成。在这项研究中，我们评估了膳食壳聚糖可能对d-半乳糖诱导的模拟衰老大鼠的血浆和红细胞样本中的全身氧化还原状态、炎症生物标志物和脂质谱可能产生的热量限制模拟 (CRM) 影响。我们发现 在加速衰老的大鼠模型中活性氧、蛋白质羰基、空腹血糖、体重、胆固醇、甘油三酯、炎症标志物——白细胞介素-6 和肿瘤坏死因子-α显着增加 ( p < 0.05)。也有显着下降（p < 0.05) 在谷胱甘肽中，衰老大鼠的晚期糖基化终产物。壳聚糖处理增加了大鼠加速衰老模型中铁还原抗氧化潜能、谷胱甘肽、质膜还原系统。我们的发现表明壳聚糖具有类似于 CRM 的特性，可以有效地维持大鼠红细胞衰老过程中的氧化还原稳态。