Background Parkinson’s disease (PD) leads to a loss of neuromelanin positive, noradrenergic neurons in the locus coeruleus (LC) which has been implicated in non-motor dysfunction. “Neuromelanin sensitive” magnetic resonance imaging (MRI) has emerged as a promising tool for mapping the structural integrity of LC in vivo.

中文翻译：

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蓝斑位点显示帕金森氏病结构解体的空间模式

背景帕金森病 (PD) 导致蓝斑 (LC) 中神经黑色素阳性的去甲肾上腺素能神经元丢失，这与非运动功能障碍有关。“神经黑色素敏感”磁共振成像 (MRI) 已成为绘制 LC 体内结构完整性的有前途的工具。