Background

: Globally, lung cancer is the leading cause of cancer associated mortalities. The current conventional chemotherapy remains the preferred treatment option for lung cancer, as surgical resection plays little role in the treatment of over 75% of lung cancer patients. Therefore, there is a need to develop novel potential therapeutic drugs or adjuvants with a high efficiency and safety against lung cancer. Scutellaria baicalensis Georgi, a common Chinese medicinal herb that has been in use for more than 2000 years, has recently been shown to possess significant activities against lung cancer. However, current research progress on pharmacological effects and relevant molecular mechanisms of S. baicalensis in lung cancer therapy have not been systematically summarized.

Purpose

: This review aimed at elucidating on the anti-lung cancer mechanisms and antitumor efficacies of S. baicalensis as well as its active ingredients, and providing a valuable reference for further investigation in this field.

Methods

: We used “Scutellaria baicalensis” or the name of the compound in S. baicalensis, in combination with “lung cancer” as key words to systematically search for relevant literature from the Web of Science and PubMed databases. Publications that investigated molecular mechanisms were the only ones selected for analysis. The PRISMA guidelines were followed.

Results

: Fifty-four publications met the inclusion criteria for this study. Five anti-lung cancer mechanisms of S. baicalensis and its constituent components are discussed. These mechanisms include apoptosis induction, cell-cycle arrest, suppression of proliferation, blockade of invasion and metastasis, and overcoming drug-resistance. These compounds exhibited high antitumor efficacies and safety against lung cancer xenografts.

Conclusion

: Studies should aim at elucidating on the anti-cancer mechanisms of S. baicalensis to achieve the ultimate goal of lung cancer therapy.

中文翻译：

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黄芩在肺癌治疗中的治疗潜力

背景

:在全球范围内，肺癌是癌症相关死亡的主要原因。目前的常规化疗仍然是肺癌的首选治疗方案，因为手术切除对超过 75% 的肺癌患者的治疗作用不大。因此，需要开发具有高效和安全性的新型潜在治疗药物或佐剂来对抗肺癌。黄芩是一种常见的中草药，已经使用了 2000 多年，最近被证明具有显着的抗肺癌活性。然而，目前关于黄芩在肺癌治疗中的药理作用及相关分子机制的研究进展尚未得到系统总结。

目的

:本综述旨在阐明黄芩及其活性成分的抗肺癌机制和抗肿瘤作用，为该领域的进一步研究提供有价值的参考。

方法

：我们使用“黄芩”或黄芩中的化合物名称，结合“肺癌”作为关键词，从Web of Science和PubMed数据库中系统检索相关文献。研究分子机制的出版物是唯一选择进行分析的出版物。遵循 PRISMA 指南。

结果

： 54 篇出版物符合本研究的纳入标准。讨论了黄芩及其组成成分的五种抗肺癌机制。这些机制包括细胞凋亡诱导、细胞周期停滞、增殖抑制、侵袭和转移阻断以及克服耐药性。这些化合物对肺癌异种移植物表现出高抗肿瘤功效和安全性。

结论

:研究应以阐明黄芩的抗癌机制为目标，以达到肺癌治疗的最终目标。