Significant porcine embryonic loss occurs during conceptus morphological elongation and attachment from d 10 to 20 of pregnancy, which directly decreases the reproductive efficiency of sows. A successful establishment of pregnancy mainly depends on the endometrium receptivity, embryo quality, and utero-placental microenvironment, which requires complex cross-talk between the conceptus and uterus. The understanding of the molecular mechanism regulating the uterine-conceptus communication during porcine conceptus elongation and attachment has developed in the past decades. Reactive oxygen and nitrogen species, which are intracellular reactive metabolites that regulate cell fate decisions and alter their biological functions, have recently reportedly been involved in porcine conceptus elongation and attachment. This mini-review will mainly focus on the recent researches about the role of reactive oxygen and nitrogen species in regulating porcine embryo development during the pre-implantation period.

在妊娠第 10 天至第 20 天的胎体形态延长和附着期间会发生显着的猪胚胎损失，这直接降低了母猪的繁殖效率。妊娠的成功建立主要取决于子宫内膜的容受性、胚胎质量和子宫胎盘微环境，这需要孕体和子宫之间复杂的串扰。在过去的几十年里，人们对在猪胎盘伸长和附着过程中调节子宫-胎盘交流的分子机制的理解有所发展。活性氧和氮物质是调节细胞命运决定并改变其生物学功能的细胞内活性代谢物，最近据报道参与了猪概念的伸长和附着。