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Annotated expression and activity data for murine recombinase alleles and transgenes: the CrePortal resource
Mammalian Genome ( IF 2.5 ) Pub Date : 2021-09-04 , DOI: 10.1007/s00335-021-09909-w
Michelle N Perry 1 , Constance M Smith 1 , Hiroaki Onda 1 , Martin Ringwald 1 , Stephen A Murray 1 , Cynthia L Smith 1
Affiliation  

Recombinase alleles and transgenes can be used to facilitate spatio-temporal specificity of gene disruption or transgene expression. However, the versatility of this in vivo recombination system relies on having detailed and accurate characterization of recombinase expression and activity to enable selection of the appropriate allele or transgene. The CrePortal (http://www.informatics.jax.org/home/recombinase) leverages the informatics infrastructure of Mouse Genome Informatics to integrate data from the scientific literature, direct data submissions from the scientific community at-large, and from major projects developing new recombinase lines and characterizing recombinase expression and specificity patterns. Searching the CrePortal by recombinase activity or specific recombinase gene driver provides users with a recombinase alleles and transgenes activity tissue summary and matrix comparison of gene expression and recombinase activity with links to generation details, a recombinase activity grid, and associated phenotype annotations. Future improvements will add cell type-based activity annotations. The CrePortal provides a comprehensive presentation of recombinase allele and transgene data to assist researchers in selection of the recombinase allele or transgene based on where and when recombination is desired.



中文翻译:

鼠重组酶等位基因和转基因的注释表达和活性数据:CrePortal 资源

重组酶等位基因和转基因可用于促进基因破坏或转基因表达的时空特异性。然而,这种体内重组系统的多功能性依赖于对重组酶表达和活性进行详细和准确的表征,以选择合适的等位基因或转基因。CrePortal (http://www.informatics.jax.org/home/recombinase) 利用 Mouse Genome Informatics 的信息基础设施来整合来自科学文献的数据、来自整个科学界的直接数据提交以及来自重大项目的数据开发新的重组酶系并表征重组酶表达和特异性模式。通过重组酶活性或特定重组酶基因驱动程序搜索 CrePortal,可为用户提供重组酶等位基因和转基因活性组织摘要以及基因表达和重组酶活性的矩阵比较,以及生成详细信息、重组酶活性网格和相关表型注释的链接。未来的改进将添加基于单元类型的活动注释。CrePortal 提供重组酶等位基因和转基因数据的全面介绍,以帮助研究人员根据需要重组的地点和时间选择重组酶等位基因或转基因。未来的改进将添加基于单元类型的活动注释。CrePortal 提供重组酶等位基因和转基因数据的全面介绍,以帮助研究人员根据需要重组的地点和时间选择重组酶等位基因或转基因。未来的改进将添加基于单元类型的活动注释。CrePortal 提供重组酶等位基因和转基因数据的全面介绍,以帮助研究人员根据需要重组的地点和时间选择重组酶等位基因或转基因。

更新日期:2021-09-04
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