During schistosomiasis, the paired Schistosoma mansoni female produces about 300 eggs each day. These eggs are responsible for the clinical picture and the transmission of the disease. During female development and egg production, fs800 is expressed only in female vitelline cells. Blast search of fs800 did not show similarities with any published sequences by NCBI. We hypothesize that the product of this gene plays a role in S. mansoni egg production. By using RNA interference to knockdown fs800 and quantitative PCR to measure the gene expression in the female schistosomes, we were able to demonstrate that fs800 product is crucial for viable egg production, it has no effect on worm health or male-female pairing. Our data suggest fs800 inhibition as a potential target to prevent transmission and pathology of schistosomiasis.

在血吸虫病期间，配对的曼氏血吸虫雌性每天产生约 300 个卵子。这些鸡蛋负责临床表现和疾病的传播。在雌性发育和产卵期间，fs800仅在雌性卵黄细胞中表达。fs800的 Blast 搜索未显示与 NCBI 发布的任何序列的相似性。我们假设该基因的产物在S. mansoni产卵中起作用。通过使用 RNA 干扰敲低fs800和定量 PCR 来测量雌性血吸虫中的基因表达，我们能够证明fs800 产品对于产卵至关重要，它对蠕虫健康或男女配对没有影响。我们的数据表明fs800抑制是预防血吸虫病传播和病理的潜在目标。