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Study on the Value of DCE-MRI in Differentiating Glossitis and Tongue Cancer and the Intratumour Heterogeneity
Cancer Management and Research ( IF 3.3 ) Pub Date : 2021-09-04 , DOI: 10.2147/cmar.s315418 Fenghai Liu 1 , Meng Zhao 1 , Shan Lu 1 , Liqing Kang 1
Cancer Management and Research ( IF 3.3 ) Pub Date : 2021-09-04 , DOI: 10.2147/cmar.s315418 Fenghai Liu 1 , Meng Zhao 1 , Shan Lu 1 , Liqing Kang 1
Affiliation
Objective: DCE-MRI is an imaging technique that reflects the blood perfusion status of the tissue’s microcirculation. The purpose of this article is to explore the clinical value of dynamic contrast-enhanced (DCE)-MRI in distinguishing benign and malignant tongue lesions and the internal heterogeneity of a tumour.
Methods: The patients were divided into a tongue cancer group (22 patients) and a glossitis group (7 patients) based on the pathology results. All of the patients underwent DCE-MRI examination.
Results: The results of this study showed that the volume transfer constant (Ktrans), rate constant (Kep), contrast enhancement ratio (CER) and initial area under the gadolinium contrast agent concentration time curve (IAUGG) values of the tongue cancer group were significantly higher than those of the glossitis group, and the difference was statistically significant (P < 0.05). However, the extravascular extracellular volume fraction (Ve), fractional plasma volume (fPV), maximum slope (MaxSlope), and bolus arrival time (BAT) values measured by DCE-MRI in the tongue cancer group were not significantly different from those in the glossitis group (P > 0.05). The results of this study showed that the Ktrans, Kep, and IAUGG values measured by DCE-MRI had a good ability to distinguish tongue inflammation from tumours and Ktrans threshold of 0.484 has the best discriminative ability among them. The mean Ktrans values of stage I–II lesions were significantly higher than that of stage III–IV lesion (p = 0.045).
Conclusion: DCE-MRI is effective in distinguishing between benign and malignant tongue lesions and the internal heterogeneity of the tumour; it is worth following up in a larger study.
Clinical Registration Number: Research registry 6393.
Keywords: DCE-MRI, tongue cancer, tumour heterogeneity, tumour microenvironment, tumour precision diagnosis and treatment
中文翻译：
DCE-MRI鉴别舌炎和舌癌的价值及瘤内异质性研究
目的： DCE-MRI是一种反映组织微循环血液灌注状态的成像技术。本文旨在探讨动态对比增强 (DCE)-MRI 在鉴别舌部良恶性病变和肿瘤内部异质性方面的临床价值。
方法：根据病理结果将患者分为舌癌组（22例）和舌炎组（7例）。所有患者均行DCE-MRI检查。
结果：本研究结果显示舌癌组的体积传递常数（Ktrans）、速率常数（Kep）、对比增强比（CER）和钆造影剂浓度时间曲线下的初始面积（IAUGG）值显着升高与舌炎组相比，差异有统计学意义（P < 0.05）。然而，舌癌组DCE-MRI测量的血管外细胞外体积分数（Ve）、血浆体积分数（fPV）、最大斜率（MaxSlope）和推注到达时间（BAT）值与舌癌组相比无显着差异。舌炎组（P > 0.05）。本研究结果表明，通过 DCE-MRI 测量的 Ktrans、Kep 和 IAUGG 值具有良好的区分舌部炎症和肿瘤的能力，Ktrans 阈值为 0。其中484的判别能力最好。I-II 期病变的平均 Ktrans 值显着高于 III-IV 期病变（p = 0.045）。
结论： DCE-MRI可有效区分舌部病变良恶性及肿瘤内部异质性；值得在更大的研究中进行跟进。
临床注册号： Research Registry 6393。
关键词： DCE-MRI，舌癌，肿瘤异质性，肿瘤微环境，肿瘤精准诊疗
更新日期：2021-09-04
Methods: The patients were divided into a tongue cancer group (22 patients) and a glossitis group (7 patients) based on the pathology results. All of the patients underwent DCE-MRI examination.
Results: The results of this study showed that the volume transfer constant (Ktrans), rate constant (Kep), contrast enhancement ratio (CER) and initial area under the gadolinium contrast agent concentration time curve (IAUGG) values of the tongue cancer group were significantly higher than those of the glossitis group, and the difference was statistically significant (P < 0.05). However, the extravascular extracellular volume fraction (Ve), fractional plasma volume (fPV), maximum slope (MaxSlope), and bolus arrival time (BAT) values measured by DCE-MRI in the tongue cancer group were not significantly different from those in the glossitis group (P > 0.05). The results of this study showed that the Ktrans, Kep, and IAUGG values measured by DCE-MRI had a good ability to distinguish tongue inflammation from tumours and Ktrans threshold of 0.484 has the best discriminative ability among them. The mean Ktrans values of stage I–II lesions were significantly higher than that of stage III–IV lesion (p = 0.045).
Conclusion: DCE-MRI is effective in distinguishing between benign and malignant tongue lesions and the internal heterogeneity of the tumour; it is worth following up in a larger study.
Clinical Registration Number: Research registry 6393.
Keywords: DCE-MRI, tongue cancer, tumour heterogeneity, tumour microenvironment, tumour precision diagnosis and treatment
中文翻译：
DCE-MRI鉴别舌炎和舌癌的价值及瘤内异质性研究
目的： DCE-MRI是一种反映组织微循环血液灌注状态的成像技术。本文旨在探讨动态对比增强 (DCE)-MRI 在鉴别舌部良恶性病变和肿瘤内部异质性方面的临床价值。
方法：根据病理结果将患者分为舌癌组（22例）和舌炎组（7例）。所有患者均行DCE-MRI检查。
结果：本研究结果显示舌癌组的体积传递常数（Ktrans）、速率常数（Kep）、对比增强比（CER）和钆造影剂浓度时间曲线下的初始面积（IAUGG）值显着升高与舌炎组相比，差异有统计学意义（P < 0.05）。然而，舌癌组DCE-MRI测量的血管外细胞外体积分数（Ve）、血浆体积分数（fPV）、最大斜率（MaxSlope）和推注到达时间（BAT）值与舌癌组相比无显着差异。舌炎组（P > 0.05）。本研究结果表明，通过 DCE-MRI 测量的 Ktrans、Kep 和 IAUGG 值具有良好的区分舌部炎症和肿瘤的能力，Ktrans 阈值为 0。其中484的判别能力最好。I-II 期病变的平均 Ktrans 值显着高于 III-IV 期病变（p = 0.045）。
结论： DCE-MRI可有效区分舌部病变良恶性及肿瘤内部异质性；值得在更大的研究中进行跟进。
临床注册号： Research Registry 6393。
关键词： DCE-MRI，舌癌，肿瘤异质性，肿瘤微环境，肿瘤精准诊疗
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