Osteoporosis, which is caused by an imbalance in osteoblasts and osteoclasts, is a global age-related metabolic disease. Osteoblasts induce osteocyte and bone matrix formation, while osteoclasts play an important role in bone resorption. Maintaining a balance between osteoblast formation and osteoclastic absorption is crucial for bone remodeling. Circular RNAs (circRNAs), which are characterized by closed-loop structures, are a class of novel endogenous transcripts with limited protein-coding abilities. Accumulating evidence indicates that circRNAs play important roles in various bone diseases, such as osteosarcoma, osteoarthritis, osteonecrosis, and osteoporosis. Recent studies have shown that circRNAs regulate osteoblast and osteoclast differentiation and may be potential biomarkers for osteoporosis. In the current review, we summarize the expression, function, and working mechanisms of circRNAs involved in osteoblasts, osteoclast differentiation, and osteoporosis.

骨质疏松症是由成骨细胞和破骨细胞失衡引起的，是一种全球性的与年龄相关的代谢疾病。成骨细胞诱导骨细胞和骨基质形成，而破骨细胞在骨吸收中起重要作用。维持成骨细胞形成和破骨细胞吸收之间的平衡对于骨重建至关重要。环状RNA（circRNA）以闭环结构为特征，是一类具有有限蛋白质编码能力的新型内源性转录本。越来越多的证据表明，circRNAs在骨肉瘤、骨关节炎、骨坏死和骨质疏松症等多种骨骼疾病中发挥着重要作用。最近的研究表明，circRNAs 调节成骨细胞和破骨细胞的分化，可能是骨质疏松症的潜在生物标志物。在目前的审查中，