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Variability in Oral Desmopressin Dose Requirements in Children with Central Diabetes Insipidus
The Journal of Pediatrics ( IF 5.1 ) Pub Date : 2021-09-04 , DOI: 10.1016/j.jpeds.2021.08.087
Nourah Almutlaq 1 , Erica A Eugster 1
Affiliation  

There is inconsistency in the amount of oral desmopressin that children with central diabetes insipidus require. We investigated whether clinical characteristics influenced desmopressin dose requirements in 100 children with central diabetes insipidus. Extremely large doses were associated with acquired etiology (P = .04), greater body mass index z score, intact thirst, and additional pituitary hormone deficiencies (P < .001).



中文翻译:

中枢性尿崩症儿童口服去氨加压素剂量要求的变异性

中枢性尿崩症患儿所需的口服去氨加压素量存在差异。我们调查了 100 名患有中枢性尿崩症的儿童的临床特征是否影响了去氨加压素的剂量需求。极大剂量与获得性病因 ( P  = .04)、更大的体重指数 z 评分、完整的口渴和额外的垂体激素缺乏有关 ( P  < .001)。

更新日期:2021-09-04
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