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Reaction of arylglyoxal hydrate derivatives with cyanoguanidine under benzilic rearrangement effect
Monatshefte für Chemie - Chemical Monthly ( IF 1.8 ) Pub Date : 2021-09-04 , DOI: 10.1007/s00706-021-02838-z
Amr H. Moustafa 1 , Bahgat R. M. Hussein 1
Affiliation  

Abstract

A novel series of (5-aryl-4-oxoimidazolidin-2-ylidene)cyanamides was successfully synthesized via the reaction of arylglyoxal hydrates with cyanoguanidine through benzilic rearrangement mechanism. The reaction was also optimized by changing various reaction factors for endeavor to increase the yield of the target product and reduce the by-product 1-cyano-3-(2-oxo-2-arylethylidene)guanidine formation.

Graphic abstract



中文翻译:

芳基乙二醛水合物衍生物与氰基胍在苄基重排作用下的反应

摘要

芳基乙二醛水合物与氰基胍通过苄基重排机制成功合成了一系列新型(5-芳基-4-氧代咪唑啉-2-亚基)氰胺。还通过改变各种反应因素来优化反应,以努力提高目标产物的产率并减少副产物 1-氰基-3-(2-氧代-2-芳基亚乙基)胍的形成。

图形摘要

更新日期:2021-09-04
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