The miR-10b-5p plays an important role in gastric cancer development but its exact effect on gastric cancer development in vivo has not been fully studied. We showed that miR-10b-5p inhibited the proliferation and migration of gastric cancer cells by down-regulating Tiam1 which was up-regulated in both gastric cancer cells and tissues. Gastric cancer xenograft experiment showed that lenti-miR-10b-5p treatment and agomir-10b-5p injection could significantly retard tumor growth and reduce tumor size and induced apoptosis. Therefore, our results elucidate the tumor suppressor role of miR-10b-5p in gastric cancer in which it acts as a negative regulator of Tiam1 and also provide a molecular mechanism for agomir-10b-5p to treat gastric cancer.

miR-10b-5p在胃癌发展中起重要作用，但其在体内对胃癌发展的确切影响尚未得到充分研究。我们发现miR-10b-5p通过下调Tiam1来抑制胃癌细胞的增殖和迁移，Tiam1在胃癌细胞和组织中均上调。胃癌异种移植实验表明，lenti-miR-10b-5p治疗和agomir-10b-5p注射可显着延缓肿瘤生长，缩小肿瘤体积并诱导细胞凋亡。因此，我们的结果阐明了 miR-10b-5p 在胃癌中的抑癌作用，其中它作为 Tiam1 的负调节因子，并为 agomir-10b-5p 治疗胃癌提供了分子机制。