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Attenuation of Rheumatoid Arthritis Through the Inhibition of Tumor Necrosis Factor–Induced Caspase 3/Gasdermin E–Mediated Pyroptosis
Arthritis & Rheumatology ( IF 13.3 ) Pub Date : 2021-09-04 , DOI: 10.1002/art.41963
Zeqing Zhai 1 , Fangyuan Yang 1 , Wenchao Xu 1 , Jiaochan Han 1 , Guihu Luo 1 , Yehao Li 1 , Jian Zhuang 1 , Hongyu Jie 1 , Xing Li 1 , Xingliang Shi 1 , Xinai Han 1 , Xiaoqing Luo 1 , Rui Song 1 , Yonghong Chen 1 , Jianheng Liang 1 , Shufan Wu 1 , Yi He 1 , Erwei Sun 1
Affiliation  

To determine the role of gasdermin E (GSDME)–mediated pyroptosis in the pathogenesis and progression of rheumatoid arthritis (RA), and to explore the potential of GSDME as a therapeutic target in RA.

中文翻译:

通过抑制肿瘤坏死因子诱导的 Caspase 3/Gasdermin E 介导的细胞焦亡减轻类风湿性关节炎

确定 gasdermin E (GSDME) 介导的细胞焦亡在类风湿性关节炎 (RA) 发病机制和进展中的作用,并探索 GSDME 作为 RA 治疗靶点的潜力。
更新日期:2021-09-04
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