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Facile solvothermal synthesis of ultrathin spinel ZnMn2O4 nanospheres: An efficient electrocatalyst for in vivo and in vitro real time monitoring of H2O2
Journal of Electroanalytical Chemistry ( IF 4.5 ) Pub Date : 2021-09-04 , DOI: 10.1016/j.jelechem.2021.115674
Muthaiah Annalakshmi, Sakthivel Kumaravel, T.S.T. Balamurugan, Shen-Ming Chen, Ju-Liang He

Hydrogen peroxide (H2O2) is a renowned industrial oxidant that plays a significant role in cell biology, and pathogenesis. On this note, we propose a simple Zinc Manganese Oxide (ZnMn2O4; ZMO) based H2O2 sensor for rapid in-situ tracking and determination of H2O2 from live cells, and bio-samples. The ZMO catalyst have been synthesized via simple scalable protocol; surface morphology, elemental composition, electronic states, crystallinity, and other physiochemical properties are studied and discussed in-detail using various spectroscopic tools. The ZMO modified electrode displays an excellent electrochemical activity toward H2O2 sensing with a wide dynamic range (20 nM-10 mM), low detection limit (8.3 nM), excellent selectivity, reproducibility, operational stability, and rapid response time (<3 s). Further, the ZMO modified electrode have been found successful at in-vivo real-time tracking of H2O2 released from live HeLa cells, and in-vitro analysis of H2O2 spiked in water, tooth paste, and human serum samples.



中文翻译:

超薄尖晶石 ZnMn2O4 纳米球的简便溶剂热合成:一种用于体内和体外实时监测 H2O2 的高效电催化剂

过氧化氢 (H 2 O 2 ) 是一种著名的工业氧化剂,在细胞生物学和发病机制中起着重要作用。在此说明中,我们提出了一种简单的基于氧化锌锰 (ZnMn 2 O 4;ZMO) 的 H 2 O 2传感器,用于快速原位跟踪和测定活细胞和生物样品中的 H 2 O 2。ZMO 催化剂是通过简单的可扩展协议合成的;使用各种光谱工具详细研究和讨论了表面形态、元素组成、电子状态、结晶度和其他理化性质。ZMO 修饰电极对 H 表现出优异的电化学活性2 O 2传感具有宽动态范围 (20 nM-10 mM)、低检测限 (8.3 nM)、出色的选择性、重现性、操作稳定性和快速响应时间 (<3 s)。此外,已发现 ZMO 修饰电极在活体HeLa 细胞释放的 H 2 O 2的体内实时跟踪以及水中、牙膏和人血清样品中掺入的 H 2 O 2的体外分析方面取得成功.

更新日期:2021-10-06
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