Background

TP73-AS1 is a novel antisense long noncoding RNA and plays an important role in cell proliferation and cancer development. However, the link between TP73-AS1 and colorectal cancer (CRC) has not yet been reported.

Objective

To explore the association of genetic variants in TP73-AS1 and its expression with CRC susceptibility and prognosis.

Methods

A case–control study (including 507 CRC cases and 503 controls) and bioinformatics analysis were conducted.

Results

rs9800 polymorphism was significantly related to higher risk in CRC [adjusted odds ratio (AOR) = 1.33, 95% confidence interval (CI) = 1.02–1.75, P = 0.034 in heterozygote codominant model]. There was no difference between TP73-AS1 polymorphisms and different tumor node metastasis (TNM) stages in the adjusted model. Moreover, TP73-AS1 expression level was positively related to different TNM stages. After adjusted for age, gender and TNM, higher TP73-AS1 expression levels were related to shorter recurrence-free survival time [hazard ratio (HR) = 1.66, 95% CI = 1.02–2.71, P = 0.043].

Conclusion

TP73-AS1 polymorphisms and expression may be associated with susceptibility and prognosis of CRC.

中文翻译：

---

一种新型反义lncRNA TP73-AS1多态性和表达与结直肠癌易感性和预后的关联

背景

TP73-AS1是一种新型反义长链非编码RNA，在细胞增殖和癌症发展中发挥重要作用。然而，尚未报道TP73-AS1与结直肠癌 (CRC) 之间的联系。

客观的

探讨TP73-AS1基因变异及其表达与CRC易感性和预后的关系。

方法

进行了病例对照研究（包括 507 例 CRC 病例和 503 例对照）和生物信息学分析。

结果

rs9800多态性与 CRC 的较高风险显着相关[在杂合子共显性模型中调整优势比 (AOR) = 1.33, 95% 置信区间 (CI) = 1.02–1.75, P  = 0.034]。在调整后的模型中， TP73-AS1多态性与不同肿瘤淋巴结转移（TNM）阶段之间没有差异。此外，TP73-AS1的表达水平与不同的TNM分期呈正相关。调整年龄、性别和 TNM 后，TP73-AS1表达水平越高，无复发生存时间越短[风险比 (HR) = 1.66, 95% CI = 1.02–2.71, P  = 0.043]。

结论

TP73-AS1的多态性和表达可能与CRC的易感性和预后有关。