Previous studies demonstrated that diabetic stroke patients had a poor prognosis and excess complement system activation in the peripheral blood. In this study, the association of serum complement levels with the prognosis of diabetic stroke was examined. Patients with acute ischemic stroke were recruited and were divided into two groups according to their history of diabetes. Baseline data on the admission, including C3 and C4 were collected. Neurologic function at discharge was the primary outcome and was quantified by the National Institutes of Health Stroke Scale (NIHSS). A total of 426 patients with acute ischemic stroke (116 diabetic strokes and 310 non-diabetic strokes) were recruited in this study. There were significant differences between the two groups in hypertension, coronary disease, triglyceride, high-density lipoprotein cholesterol, fasting blood sugar, C4, and mortality rates. Furthermore, the values of complement protein levels were divided into tertiles. In the diabetic stroke group, serum C4 level at the acute phase in the upper third was independently associated with NIHSS score at discharge and concurrent infection. These associations were not significant in non-diabetic stroke. High serum C4 level at admission, as a unique significant predictor, was associated with unfavorable clinical outcomes in the diabetic stroke, independently of traditional risk factors.

先前的研究表明，糖尿病中风患者的预后较差，外周血中补体系统激活过多。在这项研究中，研究了血清补体水平与糖尿病性卒中预后的关系。招募急性缺血性卒中患者，根据其糖尿病史分为两组。收集了入院的基线数据，包括 C3 和 C4。出院时的神经功能是主要结果，并由美国国立卫生研究院卒中量表 (NIHSS) 进行量化。本研究共招募了 426 名急性缺血性卒中患者（116 名糖尿病性卒中和 310 名非糖尿病性卒中）。两组高血压、冠心病、甘油三酯、高密度脂蛋白胆固醇、空腹血糖、C4 和死亡率。此外，补体蛋白水平的值分为三分位数。在糖尿病卒中组中，上三分之一急性期血清 C4 水平与出院时的 NIHSS 评分和并发感染独立相关。这些关联在非糖尿病性中风中不显着。入院时高血清 C4 水平作为一个独特的重要预测因子，与糖尿病性卒中的不利临床结果相关，与传统危险因素无关。这些关联在非糖尿病性中风中不显着。入院时高血清 C4 水平作为一个独特的重要预测因子，与糖尿病性卒中的不利临床结果相关，与传统危险因素无关。这些关联在非糖尿病性中风中不显着。入院时高血清 C4 水平作为一个独特的重要预测因子，与糖尿病性卒中的不利临床结果相关，与传统危险因素无关。